A transcriptional profile of aging in the human kidney.
In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2004-12-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0020427&type=printable |
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| _version_ | 1823856885632073728 |
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| author | Graham E J Rodwell Rebecca Sonu Jacob M Zahn James Lund Julie Wilhelmy Lingli Wang Wenzhong Xiao Michael Mindrinos Emily Crane Eran Segal Bryan D Myers James D Brooks Ronald W Davis John Higgins Art B Owen Stuart K Kim |
| author_facet | Graham E J Rodwell Rebecca Sonu Jacob M Zahn James Lund Julie Wilhelmy Lingli Wang Wenzhong Xiao Michael Mindrinos Emily Crane Eran Segal Bryan D Myers James D Brooks Ronald W Davis John Higgins Art B Owen Stuart K Kim |
| author_sort | Graham E J Rodwell |
| collection | DOAJ |
| description | In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. Expression profiles of these age-regulated genes mark not only age, but also the relative health and physiology of the kidney in older individuals. Finally, the set of aging-regulated kidney genes suggests specific mechanisms and pathways that may play a role in kidney degeneration with age. |
| format | Article |
| id | doaj-art-220b24b3bca64240ad25a83ca74106dc |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2004-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-220b24b3bca64240ad25a83ca74106dc2025-02-12T05:30:23ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852004-12-01212e42710.1371/journal.pbio.0020427A transcriptional profile of aging in the human kidney.Graham E J RodwellRebecca SonuJacob M ZahnJames LundJulie WilhelmyLingli WangWenzhong XiaoMichael MindrinosEmily CraneEran SegalBryan D MyersJames D BrooksRonald W DavisJohn HigginsArt B OwenStuart K KimIn this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. Expression profiles of these age-regulated genes mark not only age, but also the relative health and physiology of the kidney in older individuals. Finally, the set of aging-regulated kidney genes suggests specific mechanisms and pathways that may play a role in kidney degeneration with age.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0020427&type=printable |
| spellingShingle | Graham E J Rodwell Rebecca Sonu Jacob M Zahn James Lund Julie Wilhelmy Lingli Wang Wenzhong Xiao Michael Mindrinos Emily Crane Eran Segal Bryan D Myers James D Brooks Ronald W Davis John Higgins Art B Owen Stuart K Kim A transcriptional profile of aging in the human kidney. PLoS Biology |
| title | A transcriptional profile of aging in the human kidney. |
| title_full | A transcriptional profile of aging in the human kidney. |
| title_fullStr | A transcriptional profile of aging in the human kidney. |
| title_full_unstemmed | A transcriptional profile of aging in the human kidney. |
| title_short | A transcriptional profile of aging in the human kidney. |
| title_sort | transcriptional profile of aging in the human kidney |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0020427&type=printable |
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