A novel platform for engineered AAV-based vaccines

A novel platform for engineered AAV-based vaccines

Engineering of adeno-associated virus (AAV) capsids allowed for the development of gene therapy vectors with improved tropism and enhanced transduction efficiency. Capsid engineering can also be used to adapt the AAV technology for applications outside gene therapy. Here, we investigated modified AA...

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Bibliographic Details
Main Authors: Sabrina Babutzka, Miranda Gehrke, Anastasia Papadopoulou, Maria Diedrichs-Möhring, Maria Giannaki, Lena Hennis, Bastian Föhr, Cale Kooyman, Andreas Osterman, Evangelia Yannaki, Gerhild Wildner, Hermann Ammer, Stylianos Michalakis
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
capsid
engineered capsid
vaccine
virus-like particles
protein carrier
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125000130
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http://www.sciencedirect.com/science/article/pii/S2329050125000130

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