Increased distribution of carbon metabolic flux during de novo cytidine biosynthesis via attenuation of the acetic acid metabolism pathway in Escherichia coli

Increased distribution of carbon metabolic flux during de novo cytidine biosynthesis via attenuation of the acetic acid metabolism pathway in Escherichia coli

Abstract Acetic acid, a by-product of cytidine synthesis, competes for carbon flux from central metabolism, which may be directed either to the tricarboxylic acid (TCA) cycle for cytidine synthesis or to overflow metabolites, such as acetic acid. In Escherichia coli, the acetic acid synthesis pathwa...

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Bibliographic Details
Main Authors: Tong Ye, Wei Ding, Zhengxu An, Haojie Zhang, Xiaobo Wei, Junnan Xu, Huiyan Liu, Haitian Fang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Microbial Cell Factories
Subjects:
Acetate metabolism
Carbon metabolic flux
Cytidine
Escherichia coli
Online Access:https://doi.org/10.1186/s12934-025-02657-5
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https://doi.org/10.1186/s12934-025-02657-5

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