PCSK9 affects vascular senescence through the SIRT1 pathway

PCSK9 affects vascular senescence through the SIRT1 pathway

Age is an independent risk factor for atherosclerotic cardiovascular disease that increases the susceptibility of older adults to vascular intimal thickening, endothelial dysfunction, and thrombosis. However, the mechanism underlying vascular injury is not fully understood. In the present study, the...

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Bibliographic Details
Main Authors: Yuqin Wang, Shaoqing Cao, Zhangyu Wang, Chengsi Li, Jiangping Ye, Yehong Liu, Tianhui Jin, Yuting Zhou, Wentao Su, Gangjun Zong
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Experimental Gerontology
Subjects:
Proprotein convertase subtilisin-type kexin 9
Vascular senescence
Lipopolysaccharide
Plasmid
Small interfering RNA
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556525000294
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