Integration of single-cell and bulk RNA-sequencing data to construct and validate a signature based on NK cell marker genes to predict immunotherapy response and prognosis in colorectal cancer

Integration of single-cell and bulk RNA-sequencing data to construct and validate a signature based on NK cell marker genes to predict immunotherapy response and prognosis in colorectal cancer

Abstract We aimed to create a NK cell marker genes-based signature to predict immunotherapy response and prognosis in colorectal cancer. We integrated scRNA-seq data from four Gene Expression Omnibus (GEO) samples and performed Weighted gene correlation network analysis (WGCNA) based on 587 the Canc...

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Bibliographic Details
Main Authors: Xiaoyu Qin, Wenjuan Xu, Jinxiu Wu, Ming Li
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Discover Oncology
Subjects:
Colorectal cancer
Natural killer cells
ScRNA-seq
Immunotherapy response
Prognosis
Online Access:https://doi.org/10.1007/s12672-025-01842-7
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https://doi.org/10.1007/s12672-025-01842-7

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