Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways

Anti-TNBC effects of Lappaol F by targeting epithelial-mesenchymal transition via regulation of GSK-3β/YAP/β-catenin and PI3K/AKT pathways

PurposeLappaol F (LAF), a lignan extracted from Fructus Arctii, has a wide spectrum of anti-tumor effects, including inhibition of TNBC cell growth. However, the pharmacological mechanism of LAF targeting epithelial-mesenchymal transition (EMT) to inhibit Triple-negative breast cancer (TNBC) growth...

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Bibliographic Details
Main Authors: Qiqi Meng, Zhiping Li, Xiaofeng He, Yuanhao Hu, Guiyun Wu, Jiawen Huang, Zhuohui Luo, Yingjie Hu, Xiaoling Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
Arctium lappa L
Lappaol F
triple negative breast cancer
epithelial-mesenchymal transition
GSK-3β/YAP/β-catenin signaling
PI3K/AKT signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1496511/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1496511/full

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