Ginsenoside Rg1 alleviates chronic testicular damage caused by cranial irradiation through the SCF/PI3K/Akt/mTOR pathway in mice

Ginsenoside Rg1 alleviates chronic testicular damage caused by cranial irradiation through the SCF/PI3K/Akt/mTOR pathway in mice

Objective: To investigate whether Ginsenoside Rg1 can mitigate the adverse effects of cranial irradiation on distal reproductive function in mice and to explore the underlying mechanisms. Methods: Forty male C57BL/6J mice were randomly divided to four groups [Control, irradiation (IR), IR ​+ ​Rg1, R...

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Main Authors: Qiuhua Zhou, Yiquan Ou, Xiangsheng Tian, Yujun Ning, Yuwei Mao, Weichao Zhao, Dingxin Long
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Radiation Medicine and Protection
Subjects:
Cranial irradiation
Abscopal effects
Ginsenoside Rg1
Testicular apoptosis
HPG axis
SCF/PI3K/AKT/mTOR signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2666555724001199
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