Association between sleep during pregnancy and birth outcomes: a prospective cohort study
Abstract Objective A prospective cohort study was conducted to investigate sleep status during the early and second trimester of pregnancy in pregnant women on adverse birth outcome, such as preterm birth, low birth weight and small for gestational age. Methods Multivariable logistic regression mode...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12958-025-01350-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861464755077120 |
|---|---|
| author | Libing Huang Huanjun Chen Fuhui Yao Zhonghan Sun Shijiao Yan Yuwei Lai Chuanzhu Lv Xiong-Fei Pan Rixing Wang Xingyue Song |
| author_facet | Libing Huang Huanjun Chen Fuhui Yao Zhonghan Sun Shijiao Yan Yuwei Lai Chuanzhu Lv Xiong-Fei Pan Rixing Wang Xingyue Song |
| author_sort | Libing Huang |
| collection | DOAJ |
| description | Abstract Objective A prospective cohort study was conducted to investigate sleep status during the early and second trimester of pregnancy in pregnant women on adverse birth outcome, such as preterm birth, low birth weight and small for gestational age. Methods Multivariable logistic regression models were used to analyze the association of sleep status during the early and second trimester of pregnancy with adverse birth outcomes and generated the odds ratio and 95% confidence interval. Results 5,418 pregnant women were included in the analysis. In the multivariable model, compared with 7.1–8 h/night, sleep ≤ 7 h/night during second trimester increases the risk of preterm birth (OR: 1.43, 95% CI: 1.12,1.85), and the risk of preterm birth was decreased in pregnant women who slept > 9 h/night (OR: 0.79, 95% CI: 0.53,0.93). Sleep quality, and sleep changes in the early and second trimesters, and sleep duration in the early pregnancy were not statistically associated with preterm birth, low birth weight and small for gestational age. Conclusions Short sleep duration during pregnancy is associated with a higher risk of preterm birth and longer sleep duration at night is associated with a lower risk of preterm birth, but the latter needs further verification. Sleep status during pregnancy was not associated with low birth weight and small for gestational age. In order to reduce risk of adverse birth outcomes, sleep problems in pregnant women should be strengthened during pregnancy care. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-5033d2674ea04cb7925b4b84280c50f6 |
| institution | Kabale University |
| issn | 1477-7827 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj-art-5033d2674ea04cb7925b4b84280c50f62025-02-09T13:00:02ZengBMCReproductive Biology and Endocrinology1477-78272025-02-012311910.1186/s12958-025-01350-xAssociation between sleep during pregnancy and birth outcomes: a prospective cohort studyLibing Huang0Huanjun Chen1Fuhui Yao2Zhonghan Sun3Shijiao Yan4Yuwei Lai5Chuanzhu Lv6Xiong-Fei Pan7Rixing Wang8Xingyue Song9Department of Emergency, Zhanjiang Central People’s HospitalDanzhou Center for Disease Control and PreventionDepartment of Emergency, Hainan Clinical Research Center for Acute and Critical Diseases, The Second Affiliated Hospital of Hainan Medical UniversityHuman Phenome Institute, Fudan UniversitySchool of Public Health, Hainan Medical UniversityDepartment of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyEmergency Medicine Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaSection of Epidemiology and Population Health, Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children & National Medical Products Administration Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, West China Second University Hospital, Sichuan UniversityDepartment of Emergency, Hainan Clinical Research Center for Acute and Critical Diseases, The Second Affiliated Hospital of Hainan Medical UniversityDepartment of Emergency, Hainan Clinical Research Center for Acute and Critical Diseases, The Second Affiliated Hospital of Hainan Medical UniversityAbstract Objective A prospective cohort study was conducted to investigate sleep status during the early and second trimester of pregnancy in pregnant women on adverse birth outcome, such as preterm birth, low birth weight and small for gestational age. Methods Multivariable logistic regression models were used to analyze the association of sleep status during the early and second trimester of pregnancy with adverse birth outcomes and generated the odds ratio and 95% confidence interval. Results 5,418 pregnant women were included in the analysis. In the multivariable model, compared with 7.1–8 h/night, sleep ≤ 7 h/night during second trimester increases the risk of preterm birth (OR: 1.43, 95% CI: 1.12,1.85), and the risk of preterm birth was decreased in pregnant women who slept > 9 h/night (OR: 0.79, 95% CI: 0.53,0.93). Sleep quality, and sleep changes in the early and second trimesters, and sleep duration in the early pregnancy were not statistically associated with preterm birth, low birth weight and small for gestational age. Conclusions Short sleep duration during pregnancy is associated with a higher risk of preterm birth and longer sleep duration at night is associated with a lower risk of preterm birth, but the latter needs further verification. Sleep status during pregnancy was not associated with low birth weight and small for gestational age. In order to reduce risk of adverse birth outcomes, sleep problems in pregnant women should be strengthened during pregnancy care. Clinical trial number Not applicable.https://doi.org/10.1186/s12958-025-01350-xAdverse birth outcomesCohort studySleep durationSleep quality |
| spellingShingle | Libing Huang Huanjun Chen Fuhui Yao Zhonghan Sun Shijiao Yan Yuwei Lai Chuanzhu Lv Xiong-Fei Pan Rixing Wang Xingyue Song Association between sleep during pregnancy and birth outcomes: a prospective cohort study Reproductive Biology and Endocrinology Adverse birth outcomes Cohort study Sleep duration Sleep quality |
| title | Association between sleep during pregnancy and birth outcomes: a prospective cohort study |
| title_full | Association between sleep during pregnancy and birth outcomes: a prospective cohort study |
| title_fullStr | Association between sleep during pregnancy and birth outcomes: a prospective cohort study |
| title_full_unstemmed | Association between sleep during pregnancy and birth outcomes: a prospective cohort study |
| title_short | Association between sleep during pregnancy and birth outcomes: a prospective cohort study |
| title_sort | association between sleep during pregnancy and birth outcomes a prospective cohort study |
| topic | Adverse birth outcomes Cohort study Sleep duration Sleep quality |
| url | https://doi.org/10.1186/s12958-025-01350-x |
| work_keys_str_mv | AT libinghuang associationbetweensleepduringpregnancyandbirthoutcomesaprospectivecohortstudy AT huanjunchen associationbetweensleepduringpregnancyandbirthoutcomesaprospectivecohortstudy AT fuhuiyao associationbetweensleepduringpregnancyandbirthoutcomesaprospectivecohortstudy AT zhonghansun associationbetweensleepduringpregnancyandbirthoutcomesaprospectivecohortstudy AT shijiaoyan associationbetweensleepduringpregnancyandbirthoutcomesaprospectivecohortstudy AT yuweilai associationbetweensleepduringpregnancyandbirthoutcomesaprospectivecohortstudy AT chuanzhulv associationbetweensleepduringpregnancyandbirthoutcomesaprospectivecohortstudy AT xiongfeipan associationbetweensleepduringpregnancyandbirthoutcomesaprospectivecohortstudy AT rixingwang associationbetweensleepduringpregnancyandbirthoutcomesaprospectivecohortstudy AT xingyuesong associationbetweensleepduringpregnancyandbirthoutcomesaprospectivecohortstudy |