Liver transcriptome analysis reveals PSC-attributed gene set associated with fibrosis progression

Liver transcriptome analysis reveals PSC-attributed gene set associated with fibrosis progression

Background & Aims: Primary sclerosing cholangitis (PSC) is a chronic heterogenous cholangiopathy with unknown etiology where chronic inflammation of the bile ducts leads to multifocal biliary strictures and biliary fibrosis with consecutive cirrhosis development. We here aimed to identify a...

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Main Authors: Alena Laschtowitz, Eric L. Lindberg, Anna-Maria Liebhoff, Laura Anne Liebig, Christian Casar, Silja Steinmann, Adrien Guillot, Jun Xu, Dorothee Schwinge, Michael Trauner, Ansgar Wilhelm Lohse, Stefan Bonn, Norbert Hübner, Christoph Schramm
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:JHEP Reports
Subjects:
Primary sclerosing cholangitis
Biliary fibrosis
Bulk RNA-sequencing
Liver transcriptome
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924002714
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