Liver macrophage-derived exosomal miRNA-342-3p promotes liver fibrosis by inhibiting HPCAL1 in stellate cells

Liver macrophage-derived exosomal miRNA-342-3p promotes liver fibrosis by inhibiting HPCAL1 in stellate cells

Abstract Background The progression of liver fibrosis involves complex interactions between hepatic stellate cells (HSCs) and multiple immune cells in the liver, including macrophages. However, the mechanism of exosomes in the crosstalk between liver macrophages and HSCs remains unclear. Method Exos...

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Bibliographic Details
Main Authors: Wenshuai Li, Lirong Chen, Qi Zhou, Tiansheng Huang, Wanwei Zheng, Feifei Luo, Zhong Guang Luo, Jun Zhang, Jie Liu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Human Genomics
Subjects:
Liver fibrosis
Liver macrophage
Exosome
Hepatic stellate cells
MiRNA-342-3p
Online Access:https://doi.org/10.1186/s40246-025-00722-z
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