CX3CR1+ age-associated CD4+ T cells contribute to synovial inflammation in late-onset rheumatoid arthritis

CX3CR1+ age-associated CD4+ T cells contribute to synovial inflammation in late-onset rheumatoid arthritis

Abstract Background Recent evidence suggests that clonally expanded cytotoxic T cells play a role in various autoimmune diseases. Late-onset rheumatoid arthritis (LORA) exhibits unique characteristics compared to other RA forms, suggesting distinct immunological mechanisms. This study aimed to exami...

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Main Authors: Mitsuhiro Akiyama, Sohma Wakasugi, Keiko Yoshimoto, Koichi Saito, Sho Ishigaki, Risa Inukai, Yoshiyuki Matsuno, Waleed Alshehri, Yasushi Kondo, Yuko Kaneko
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Inflammation and Regeneration
Subjects:
CX3CR1
Cytotoxic T cells
Aging
Rheumatoid arthritis
Late-onset rheumatoid arthritis
Difficult-to-treat rheumatoid arthritis
Online Access:https://doi.org/10.1186/s41232-025-00367-4
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https://doi.org/10.1186/s41232-025-00367-4

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