Comprehensive landscape and oncogenic role of extrachromosomal circular DNA in malignant biliary strictures

Comprehensive landscape and oncogenic role of extrachromosomal circular DNA in malignant biliary strictures

Abstract Background Extrachromosomal circular DNA (eccDNA) is crucial for carcinogenesis and bile has direct contact with malignant biliary strictures, yet eccDNA features in bile and its function in malignant biliary strictures remain underexplored. Results We observed the widespread presence of ec...

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Bibliographic Details
Main Authors: Zhuo Cheng, Xuanmei Luo, Wenzheng Liu, Xiaofang Lu, Hong Chang, Yingchun Wang, Wei Zheng, Xiue Yan, Yonghui Huang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell & Bioscience
Subjects:
Malignant biliary strictures
Bile cell-free extrachromosomal circular DNA
Diagnostic biomarkers
Liquid biopsy assay
Nanopore sequencing
Carcinogenesis
Online Access:https://doi.org/10.1186/s13578-025-01361-6
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https://doi.org/10.1186/s13578-025-01361-6

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