Clinical presentation, diagnosis and treatment of intrahepatic cholestasis of pregnancy
Aim of the lecture. To present the modern concept of etiology and pathogenesis of the intrahepatic cholestasis of pregnancy (ICP) and the modern diagnostic and treatment approaches to gastroenterologists. Summary. The etiology and pathogenesis of ICP are related to disorders of bile acid metabolism...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2018-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/172 |
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| author | Yu. B. Uspenskaya A. A. Sheptulin |
| author_facet | Yu. B. Uspenskaya A. A. Sheptulin |
| author_sort | Yu. B. Uspenskaya |
| collection | DOAJ |
| description | Aim of the lecture. To present the modern concept of etiology and pathogenesis of the intrahepatic cholestasis of pregnancy (ICP) and the modern diagnostic and treatment approaches to gastroenterologists. Summary. The etiology and pathogenesis of ICP are related to disorders of bile acid metabolism caused by hormonal factors (elevation of estrogen and progesterone levels) and genetic predisposition. The leading clinical signs of ICP include pruritus and jaundice that develop most commonly in the third trimester of pregnancy, and characteristic changes of laboratory scores: increase in bile acid level (over 10 mcmol/l) and moderate elevation of transaminase activity. Severity of ICP and complication risk for mother and fetus correlate to the degree of bile acids elevation. The most effective agent for ICP treatment is ursodeoxycholic acid (UDCA). Conclusion. Timely diagnostics of ICP and early UDCA administration, fetus condition control and early delivery at severe ICP cases allows to prevent development of serious complications and to achieve favorable pregnancy outcome. |
| format | Article |
| id | doaj-art-649393f242f641e39a3d0e5274d4f1ba |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-649393f242f641e39a3d0e5274d4f1ba2025-02-10T16:14:29ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-012749610110.22416/1382-4376-2017-27-4-96-101172Clinical presentation, diagnosis and treatment of intrahepatic cholestasis of pregnancyYu. B. Uspenskaya0A. A. Sheptulin1Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical UniversityFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical UniversityAim of the lecture. To present the modern concept of etiology and pathogenesis of the intrahepatic cholestasis of pregnancy (ICP) and the modern diagnostic and treatment approaches to gastroenterologists. Summary. The etiology and pathogenesis of ICP are related to disorders of bile acid metabolism caused by hormonal factors (elevation of estrogen and progesterone levels) and genetic predisposition. The leading clinical signs of ICP include pruritus and jaundice that develop most commonly in the third trimester of pregnancy, and characteristic changes of laboratory scores: increase in bile acid level (over 10 mcmol/l) and moderate elevation of transaminase activity. Severity of ICP and complication risk for mother and fetus correlate to the degree of bile acids elevation. The most effective agent for ICP treatment is ursodeoxycholic acid (UDCA). Conclusion. Timely diagnostics of ICP and early UDCA administration, fetus condition control and early delivery at severe ICP cases allows to prevent development of serious complications and to achieve favorable pregnancy outcome.https://www.gastro-j.ru/jour/article/view/172беременностьвнутрипеченочный холестазжёлчные кислотыурсодеоксихолевая кислота |
| spellingShingle | Yu. B. Uspenskaya A. A. Sheptulin Clinical presentation, diagnosis and treatment of intrahepatic cholestasis of pregnancy Российский журнал гастроэнтерологии, гепатологии, колопроктологии беременность внутрипеченочный холестаз жёлчные кислоты урсодеоксихолевая кислота |
| title | Clinical presentation, diagnosis and treatment of intrahepatic cholestasis of pregnancy |
| title_full | Clinical presentation, diagnosis and treatment of intrahepatic cholestasis of pregnancy |
| title_fullStr | Clinical presentation, diagnosis and treatment of intrahepatic cholestasis of pregnancy |
| title_full_unstemmed | Clinical presentation, diagnosis and treatment of intrahepatic cholestasis of pregnancy |
| title_short | Clinical presentation, diagnosis and treatment of intrahepatic cholestasis of pregnancy |
| title_sort | clinical presentation diagnosis and treatment of intrahepatic cholestasis of pregnancy |
| topic | беременность внутрипеченочный холестаз жёлчные кислоты урсодеоксихолевая кислота |
| url | https://www.gastro-j.ru/jour/article/view/172 |
| work_keys_str_mv | AT yubuspenskaya clinicalpresentationdiagnosisandtreatmentofintrahepaticcholestasisofpregnancy AT aasheptulin clinicalpresentationdiagnosisandtreatmentofintrahepaticcholestasisofpregnancy |