Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation

Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation

Abstract Background Lung cancer patients with comorbid interstitial lung disease (LC-ILD) have an increased risk of developing severe or even fatal radiation pneumonitis after thoracic radiotherapy. However, the underlying mechanisms of its pathogenesis are still inconclusive. No approved biomarker...

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Bibliographic Details
Main Authors: Jiamei Fu, Xinglong Liu, Yuchuan Zhou, Shengnan Zhao, Liang Zeng, Yan Pan, Jianghong Zhang, Kevin M. Prise, Chunlin Shao, Yaping Xu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Radiation Oncology
Subjects:
Animal model
Severe lung injury
Radiation
Interstitial lung disease
Diffuse alveolar damage
Online Access:https://doi.org/10.1186/s13014-025-02596-w
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