Harnessing amino acid pathways to influence myeloid cell function in tumor immunity
Abstract Amino acids are pivotal regulators of immune cell metabolism, signaling pathways, and gene expression. In myeloid cells, these processes underlie their functional plasticity, enabling shifts between pro-inflammatory, anti-inflammatory, pro-tumor, and anti-tumor activities. Within the tumor...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Molecular Medicine |
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| Online Access: | https://doi.org/10.1186/s10020-025-01099-4 |
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| author | Jiongli Pan Yi Lin Xinyuan Liu Xiaozhen Zhang Tingbo Liang Xueli Bai |
| author_facet | Jiongli Pan Yi Lin Xinyuan Liu Xiaozhen Zhang Tingbo Liang Xueli Bai |
| author_sort | Jiongli Pan |
| collection | DOAJ |
| description | Abstract Amino acids are pivotal regulators of immune cell metabolism, signaling pathways, and gene expression. In myeloid cells, these processes underlie their functional plasticity, enabling shifts between pro-inflammatory, anti-inflammatory, pro-tumor, and anti-tumor activities. Within the tumor microenvironment, amino acid metabolism plays a crucial role in mediating the immunosuppressive functions of myeloid cells, contributing to tumor progression. This review delves into the mechanisms by which specific amino acids—glutamine, serine, arginine, and tryptophan—regulate myeloid cell function and polarization. Furthermore, we explore the therapeutic potential of targeting amino acid metabolism to enhance anti-tumor immunity, offering insights into novel strategies for cancer treatment. |
| format | Article |
| id | doaj-art-67f3b9e59ecc4f1e9d2a6cf6f040d492 |
| institution | Kabale University |
| issn | 1528-3658 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj-art-67f3b9e59ecc4f1e9d2a6cf6f040d4922025-02-09T12:42:15ZengBMCMolecular Medicine1528-36582025-02-0131112010.1186/s10020-025-01099-4Harnessing amino acid pathways to influence myeloid cell function in tumor immunityJiongli Pan0Yi Lin1Xinyuan Liu2Xiaozhen Zhang3Tingbo Liang4Xueli Bai5Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityHealth Science Center, Ningbo UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityAbstract Amino acids are pivotal regulators of immune cell metabolism, signaling pathways, and gene expression. In myeloid cells, these processes underlie their functional plasticity, enabling shifts between pro-inflammatory, anti-inflammatory, pro-tumor, and anti-tumor activities. Within the tumor microenvironment, amino acid metabolism plays a crucial role in mediating the immunosuppressive functions of myeloid cells, contributing to tumor progression. This review delves into the mechanisms by which specific amino acids—glutamine, serine, arginine, and tryptophan—regulate myeloid cell function and polarization. Furthermore, we explore the therapeutic potential of targeting amino acid metabolism to enhance anti-tumor immunity, offering insights into novel strategies for cancer treatment.https://doi.org/10.1186/s10020-025-01099-4Amino acid metabolismMyeloid cellsImmunometabolismMetabolic reprogrammingCancer immunotherapy |
| spellingShingle | Jiongli Pan Yi Lin Xinyuan Liu Xiaozhen Zhang Tingbo Liang Xueli Bai Harnessing amino acid pathways to influence myeloid cell function in tumor immunity Molecular Medicine Amino acid metabolism Myeloid cells Immunometabolism Metabolic reprogramming Cancer immunotherapy |
| title | Harnessing amino acid pathways to influence myeloid cell function in tumor immunity |
| title_full | Harnessing amino acid pathways to influence myeloid cell function in tumor immunity |
| title_fullStr | Harnessing amino acid pathways to influence myeloid cell function in tumor immunity |
| title_full_unstemmed | Harnessing amino acid pathways to influence myeloid cell function in tumor immunity |
| title_short | Harnessing amino acid pathways to influence myeloid cell function in tumor immunity |
| title_sort | harnessing amino acid pathways to influence myeloid cell function in tumor immunity |
| topic | Amino acid metabolism Myeloid cells Immunometabolism Metabolic reprogramming Cancer immunotherapy |
| url | https://doi.org/10.1186/s10020-025-01099-4 |
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