Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma
Abstract Radiotherapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC). However, the tumor microenvironment (TME)-induced radioresistance often compromises its therapeutic efficacy. Herein, we propose an innovative bidirectional radiosensitization strategy for NPC. Specifica...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03177-5 |
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| author | Jie Chen Chengyu Feng Yufei Lan Xiangtian Chen Zhengqi Peng Zihan Huang Ruiqing Wang Wenxin Zhang Yingying Ye Zhilei Mao Dongyue Pan Lihua Yang |
| author_facet | Jie Chen Chengyu Feng Yufei Lan Xiangtian Chen Zhengqi Peng Zihan Huang Ruiqing Wang Wenxin Zhang Yingying Ye Zhilei Mao Dongyue Pan Lihua Yang |
| author_sort | Jie Chen |
| collection | DOAJ |
| description | Abstract Radiotherapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC). However, the tumor microenvironment (TME)-induced radioresistance often compromises its therapeutic efficacy. Herein, we propose an innovative bidirectional radiosensitization strategy for NPC. Specifically, we have encapsulated metformin (Met) and copper sulfide nanoparticles (CuS NPs) within injectable DNA supramolecular hydrogels (DSH) to create a novel radiosensitizer, Met-CuS@DSH. This radiosensitizer not only effectively reverses tumor hypoxia to promote reactive oxygen species (ROS) generation but also significantly inhibits glutathione (GSH)-mediated ROS scavenging, thereby achieving bidirectional radiosensitization by enhancing ROS production and suppressing its scavenging. This strategy significantly improves the therapeutic effect of NPC while reducing the RT dose (3 Gy in total), which provides a promising approach for overcoming the radioresistance of NPC caused by TME. Graphical Abstract |
| format | Article |
| id | doaj-art-697ede3e07a240a88533e69de8806d88 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-697ede3e07a240a88533e69de8806d882025-02-09T12:53:00ZengBMCJournal of Nanobiotechnology1477-31552025-02-0123111910.1186/s12951-025-03177-5Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinomaJie Chen0Chengyu Feng1Yufei Lan2Xiangtian Chen3Zhengqi Peng4Zihan Huang5Ruiqing Wang6Wenxin Zhang7Yingying Ye8Zhilei Mao9Dongyue Pan10Lihua Yang11Department of Oncology, Zhujiang Hospital, Southern Medical UniversityDepartment of Pediatric Hematology, Zhujiang Hospital, Southern Medical UniversityDepartment of Neurosurgery, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China On Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory On Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical UniversityDepartment of Pathology, Zhujiang Hospital, Southern Medical UniversityDepartment of General Surgery, Zhujiang Hospital, Southern Medical UniversityDepartment of Pediatric Hematology, Zhujiang Hospital, Southern Medical UniversityDepartment of Pediatric Hematology, Zhujiang Hospital, Southern Medical UniversityDepartment of Pediatric Hematology, Zhujiang Hospital, Southern Medical UniversityDepartment of Oncology, Zhujiang Hospital, Southern Medical UniversityDepartment of Children Healthcare Center, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical UniversityThe Breast Center, Cancer Hospital, Shantou University Medical CollegeDepartment of Pediatric Hematology, Zhujiang Hospital, Southern Medical UniversityAbstract Radiotherapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC). However, the tumor microenvironment (TME)-induced radioresistance often compromises its therapeutic efficacy. Herein, we propose an innovative bidirectional radiosensitization strategy for NPC. Specifically, we have encapsulated metformin (Met) and copper sulfide nanoparticles (CuS NPs) within injectable DNA supramolecular hydrogels (DSH) to create a novel radiosensitizer, Met-CuS@DSH. This radiosensitizer not only effectively reverses tumor hypoxia to promote reactive oxygen species (ROS) generation but also significantly inhibits glutathione (GSH)-mediated ROS scavenging, thereby achieving bidirectional radiosensitization by enhancing ROS production and suppressing its scavenging. This strategy significantly improves the therapeutic effect of NPC while reducing the RT dose (3 Gy in total), which provides a promising approach for overcoming the radioresistance of NPC caused by TME. Graphical Abstracthttps://doi.org/10.1186/s12951-025-03177-5DNA hydrogelMetforminCopper sulfideRadiosensitizerReactive oxygen species |
| spellingShingle | Jie Chen Chengyu Feng Yufei Lan Xiangtian Chen Zhengqi Peng Zihan Huang Ruiqing Wang Wenxin Zhang Yingying Ye Zhilei Mao Dongyue Pan Lihua Yang Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma Journal of Nanobiotechnology DNA hydrogel Metformin Copper sulfide Radiosensitizer Reactive oxygen species |
| title | Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma |
| title_full | Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma |
| title_fullStr | Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma |
| title_full_unstemmed | Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma |
| title_short | Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma |
| title_sort | bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma |
| topic | DNA hydrogel Metformin Copper sulfide Radiosensitizer Reactive oxygen species |
| url | https://doi.org/10.1186/s12951-025-03177-5 |
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