Association between Dietary Total Antioxidant Capacity and Odds of Preeclampsia: A Case-control Study
Background: Preeclampsia may cause maternal and child morbidity and mortality. Evidence suggests that oxidative stress may be involved in the development of preeclampsia; however, the role of dietary total antioxidant capacity (DTAC) on preeclampsia risk has not yet been elucidated. Thus, this study...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahid Sadoughi University of Medical Sciences and Health Services
2025-02-01
|
| Series: | Journal of Nutrition and Food Security |
| Subjects: | |
| Online Access: | http://jnfs.ssu.ac.ir/article-1-912-en.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823865249409794048 |
|---|---|
| author | Mahshid Taherkhani Farzaneh Montazerifar Azita Hekmatdoost Bahram Rashidkhani Abolfazl Payandeh Mansour Karajibani |
| author_facet | Mahshid Taherkhani Farzaneh Montazerifar Azita Hekmatdoost Bahram Rashidkhani Abolfazl Payandeh Mansour Karajibani |
| author_sort | Mahshid Taherkhani |
| collection | DOAJ |
| description | Background: Preeclampsia may cause maternal and child morbidity and mortality. Evidence suggests that oxidative stress may be involved in the development of preeclampsia; however, the role of dietary total antioxidant capacity (DTAC) on preeclampsia risk has not yet been elucidated. Thus, this study aims to assess the relationship between DTAC and odds of preeclampsia. Methods: This case-control study was conducted on 240 pregnant women (preeclampsia, n=60; controls, n=180) in Qazvin, Iran. Controls were 3:1 ratio matched with cases in terms of participants’ age and gestational age. Dietary intakes were assessed using a validated food frequency questionnaire evaluating the preceding year. DTAC was measured by two methods: ferric reducing antioxidant potential (FRAP) and oxygen radical absorbance capacity (ORAC). Multivariable logistic regression was employed to evaluate the association between preeclampsia and DTAC and also selected antioxidants. Results: After controlling for potential confounders, a significant inverse relationship was found between ORAC and preeclampsia; individuals in the highest tertile of ORAC were 67% less likely to have preeclampsia than those in the lowest tertile of ORAC (OR: 0.33; 95% CI: 0.11-0.97; P-trend<0.05). There was no significant relation between FRAP and preeclampsia. The risk of preeclampsia was 70% lower among subjects with the highest tertile of vitamin C intake compared to the lowest tertile of it. Conclusion: Pregnant women with the highest tertile of ORAC and vitamin C intake were at lower risk of preeclampsia. Therefore, prospective studies are needed to confirm the protective effects of dietary anti-oxidants on preeclampsia incidence. |
| format | Article |
| id | doaj-art-7652dea3057a4ff0aa45508fd5cc584f |
| institution | Kabale University |
| issn | 2476-7417 2476-7425 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Shahid Sadoughi University of Medical Sciences and Health Services |
| record_format | Article |
| series | Journal of Nutrition and Food Security |
| spelling | doaj-art-7652dea3057a4ff0aa45508fd5cc584f2025-02-08T10:57:36ZengShahid Sadoughi University of Medical Sciences and Health ServicesJournal of Nutrition and Food Security2476-74172476-74252025-02-011016980Association between Dietary Total Antioxidant Capacity and Odds of Preeclampsia: A Case-control StudyMahshid Taherkhani0Farzaneh Montazerifar1Azita Hekmatdoost2Bahram Rashidkhani3Abolfazl Payandeh4Mansour Karajibani5 Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Pregnancy Health Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran Department of Biostatistics and Epidemiology, School of Health, Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Health Promotion Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Background: Preeclampsia may cause maternal and child morbidity and mortality. Evidence suggests that oxidative stress may be involved in the development of preeclampsia; however, the role of dietary total antioxidant capacity (DTAC) on preeclampsia risk has not yet been elucidated. Thus, this study aims to assess the relationship between DTAC and odds of preeclampsia. Methods: This case-control study was conducted on 240 pregnant women (preeclampsia, n=60; controls, n=180) in Qazvin, Iran. Controls were 3:1 ratio matched with cases in terms of participants’ age and gestational age. Dietary intakes were assessed using a validated food frequency questionnaire evaluating the preceding year. DTAC was measured by two methods: ferric reducing antioxidant potential (FRAP) and oxygen radical absorbance capacity (ORAC). Multivariable logistic regression was employed to evaluate the association between preeclampsia and DTAC and also selected antioxidants. Results: After controlling for potential confounders, a significant inverse relationship was found between ORAC and preeclampsia; individuals in the highest tertile of ORAC were 67% less likely to have preeclampsia than those in the lowest tertile of ORAC (OR: 0.33; 95% CI: 0.11-0.97; P-trend<0.05). There was no significant relation between FRAP and preeclampsia. The risk of preeclampsia was 70% lower among subjects with the highest tertile of vitamin C intake compared to the lowest tertile of it. Conclusion: Pregnant women with the highest tertile of ORAC and vitamin C intake were at lower risk of preeclampsia. Therefore, prospective studies are needed to confirm the protective effects of dietary anti-oxidants on preeclampsia incidence.http://jnfs.ssu.ac.ir/article-1-912-en.pdfhypertensionantioxidantsoxidative stresspreeclampsiaoxygen radical absorbance capacitydiet. |
| spellingShingle | Mahshid Taherkhani Farzaneh Montazerifar Azita Hekmatdoost Bahram Rashidkhani Abolfazl Payandeh Mansour Karajibani Association between Dietary Total Antioxidant Capacity and Odds of Preeclampsia: A Case-control Study Journal of Nutrition and Food Security hypertension antioxidants oxidative stress preeclampsia oxygen radical absorbance capacity diet. |
| title | Association between Dietary Total Antioxidant Capacity and Odds of Preeclampsia: A Case-control Study |
| title_full | Association between Dietary Total Antioxidant Capacity and Odds of Preeclampsia: A Case-control Study |
| title_fullStr | Association between Dietary Total Antioxidant Capacity and Odds of Preeclampsia: A Case-control Study |
| title_full_unstemmed | Association between Dietary Total Antioxidant Capacity and Odds of Preeclampsia: A Case-control Study |
| title_short | Association between Dietary Total Antioxidant Capacity and Odds of Preeclampsia: A Case-control Study |
| title_sort | association between dietary total antioxidant capacity and odds of preeclampsia a case control study |
| topic | hypertension antioxidants oxidative stress preeclampsia oxygen radical absorbance capacity diet. |
| url | http://jnfs.ssu.ac.ir/article-1-912-en.pdf |
| work_keys_str_mv | AT mahshidtaherkhani associationbetweendietarytotalantioxidantcapacityandoddsofpreeclampsiaacasecontrolstudy AT farzanehmontazerifar associationbetweendietarytotalantioxidantcapacityandoddsofpreeclampsiaacasecontrolstudy AT azitahekmatdoost associationbetweendietarytotalantioxidantcapacityandoddsofpreeclampsiaacasecontrolstudy AT bahramrashidkhani associationbetweendietarytotalantioxidantcapacityandoddsofpreeclampsiaacasecontrolstudy AT abolfazlpayandeh associationbetweendietarytotalantioxidantcapacityandoddsofpreeclampsiaacasecontrolstudy AT mansourkarajibani associationbetweendietarytotalantioxidantcapacityandoddsofpreeclampsiaacasecontrolstudy |