The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver Disease
Aim. To review available data on the role of the microbiome and intestinal mucosal barrier in the development and progression of non-alcoholic fatty liver disease (NAFLD).Key points. The role of the human microbiome in the development and progression of NAFLD is associated with its effects on the ri...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2020-12-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/530 |
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| _version_ | 1823860139495522304 |
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| author | T. S. Krolevets M. A. Livzan S. I. Mozgovoy |
| author_facet | T. S. Krolevets M. A. Livzan S. I. Mozgovoy |
| author_sort | T. S. Krolevets |
| collection | DOAJ |
| description | Aim. To review available data on the role of the microbiome and intestinal mucosal barrier in the development and progression of non-alcoholic fatty liver disease (NAFLD).Key points. The role of the human microbiome in the development and progression of NAFLD is associated with its effects on the risk factors (obesity, insulin resistance, type 2 diabetes), permeability of the intestinal barrier and absorption of such substances as short-chain fatty acids, bile acids, choline and endogenous ethanol. Liver fibrosis constitutes the leading factor determining the prognosis of patients in NAFLD, including cases associated with cardiovascular complications. Changes in the microbiome composition were demonstrated for various degrees of fibrosis in NAFLD.Conclusion. The results of modern studies confirm the formation of a new concept in the pathophysiology of NAFLD, which encourages the development of new therapeutic strategies. |
| format | Article |
| id | doaj-art-82effa29c947410e9d586ef00128c709 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-82effa29c947410e9d586ef00128c7092025-02-10T16:14:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732020-12-01305424810.22416/1382-4376-2020-30-5-42-48395The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver DiseaseT. S. Krolevets0M. A. Livzan1S. I. Mozgovoy2Omsk State Medical UniversityOmsk State Medical UniversityOmsk State Medical UniversityAim. To review available data on the role of the microbiome and intestinal mucosal barrier in the development and progression of non-alcoholic fatty liver disease (NAFLD).Key points. The role of the human microbiome in the development and progression of NAFLD is associated with its effects on the risk factors (obesity, insulin resistance, type 2 diabetes), permeability of the intestinal barrier and absorption of such substances as short-chain fatty acids, bile acids, choline and endogenous ethanol. Liver fibrosis constitutes the leading factor determining the prognosis of patients in NAFLD, including cases associated with cardiovascular complications. Changes in the microbiome composition were demonstrated for various degrees of fibrosis in NAFLD.Conclusion. The results of modern studies confirm the formation of a new concept in the pathophysiology of NAFLD, which encourages the development of new therapeutic strategies.https://www.gastro-j.ru/jour/article/view/530intestinal mucosal barriernon-alcoholic fatty liver diseasefibrosismicrobiota |
| spellingShingle | T. S. Krolevets M. A. Livzan S. I. Mozgovoy The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver Disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии intestinal mucosal barrier non-alcoholic fatty liver disease fibrosis microbiota |
| title | The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver Disease |
| title_full | The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver Disease |
| title_fullStr | The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver Disease |
| title_full_unstemmed | The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver Disease |
| title_short | The Role of the Microbiome and Intestinal Mucosal Barrier in the Development and Progression of Non-Alcoholic Fatty Liver Disease |
| title_sort | role of the microbiome and intestinal mucosal barrier in the development and progression of non alcoholic fatty liver disease |
| topic | intestinal mucosal barrier non-alcoholic fatty liver disease fibrosis microbiota |
| url | https://www.gastro-j.ru/jour/article/view/530 |
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