Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis
Lingling Zhu,1– 3 Linglin Tian,3 Suxia Li,1 Lijuan Huo3 1First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Linfen Vocational and Technical College, Linfen, Shanxi, People’s Republic of China; 3Department of Gastroenterology, First Hospital of Sh...
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Dove Medical Press
2025-02-01
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| author | Zhu L Tian L Li S Huo L |
| author_facet | Zhu L Tian L Li S Huo L |
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| description | Lingling Zhu,1– 3 Linglin Tian,3 Suxia Li,1 Lijuan Huo3 1First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Linfen Vocational and Technical College, Linfen, Shanxi, People’s Republic of China; 3Department of Gastroenterology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of ChinaCorrespondence: Lijuan Huo, Department of Gastroenterology, First Hospital of Shanxi Medical University, 85 Jiefang South Road, Taiyuan, 030001, Shanxi, People’s Republic of China, Tel +86-13835107953, Email [email protected]: There is limited research on the correlation between blood lipid levels and severe ulcerative colitis, and this article helps to reveal the relationship between the two. This study aimed to explore the relationship between blood lipid levels and disease activity, and to evaluate the early predictive value of blood lipid levels for severe ulcerative colitis (UC).Patients and Methods: Here, we analyzed blood lipid indicators of 210 patients with UC and 210 healthy individuals who visited the hospital between August 2018 and August 2022. We divided the patients with UC into non-severe and severe groups, analyzed the relationship between blood lipid levels and severe UC, and evaluated the early predictive value of blood lipid indicators for severe UC.Results: Compared with healthy individuals, patients with UC had lower total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and non-HDL-C levels (P< 0.05). Patients with severe versus non-severe UC had decreased TC, HDL-C, LDL-C, and non-HDL-C levels (P< 0.05). The combined detection of TC level and erythrocyte sedimentation rate (ESR) predicted a working characteristic receiver operating characteristic curve area of 0.768 (0.694– 0.841) in patients with severe UC, which had good early predictive value with a sensitivity of 77.0% and specificity of 66.7%.Conclusion: TC, HDL-C, LDL-C, and non-HDL-C levels were decreased in patients with severe UC. Combined TC levels and ESRs had good early predictive value for severe UC.Keywords: erythrocyte sedimentation rate, high-density lipoprotein cholesterol, lipid levels, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, severe ulcerative colitis, total cholesterol, triglyceride, ulcerative colitis |
| format | Article |
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| spelling | doaj-art-85156cc9225540de91082fa427d91fd12025-02-11T17:30:55ZengDove Medical PressInternational Journal of General Medicine1178-70742025-02-01Volume 18671680100040Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative ColitisZhu LTian LLi SHuo LLingling Zhu,1– 3 Linglin Tian,3 Suxia Li,1 Lijuan Huo3 1First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Linfen Vocational and Technical College, Linfen, Shanxi, People’s Republic of China; 3Department of Gastroenterology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of ChinaCorrespondence: Lijuan Huo, Department of Gastroenterology, First Hospital of Shanxi Medical University, 85 Jiefang South Road, Taiyuan, 030001, Shanxi, People’s Republic of China, Tel +86-13835107953, Email [email protected]: There is limited research on the correlation between blood lipid levels and severe ulcerative colitis, and this article helps to reveal the relationship between the two. This study aimed to explore the relationship between blood lipid levels and disease activity, and to evaluate the early predictive value of blood lipid levels for severe ulcerative colitis (UC).Patients and Methods: Here, we analyzed blood lipid indicators of 210 patients with UC and 210 healthy individuals who visited the hospital between August 2018 and August 2022. We divided the patients with UC into non-severe and severe groups, analyzed the relationship between blood lipid levels and severe UC, and evaluated the early predictive value of blood lipid indicators for severe UC.Results: Compared with healthy individuals, patients with UC had lower total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and non-HDL-C levels (P< 0.05). Patients with severe versus non-severe UC had decreased TC, HDL-C, LDL-C, and non-HDL-C levels (P< 0.05). The combined detection of TC level and erythrocyte sedimentation rate (ESR) predicted a working characteristic receiver operating characteristic curve area of 0.768 (0.694– 0.841) in patients with severe UC, which had good early predictive value with a sensitivity of 77.0% and specificity of 66.7%.Conclusion: TC, HDL-C, LDL-C, and non-HDL-C levels were decreased in patients with severe UC. Combined TC levels and ESRs had good early predictive value for severe UC.Keywords: erythrocyte sedimentation rate, high-density lipoprotein cholesterol, lipid levels, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, severe ulcerative colitis, total cholesterol, triglyceride, ulcerative colitishttps://www.dovepress.com/blood-lipid-levels-and-their-value-as-markers-of-disease-activity-in-s-peer-reviewed-fulltext-article-IJGMerythrocyte sedimentation ratehigh-density lipoprotein cholesterollipid levelslow-density lipoprotein cholesterolnon-high-density lipoprotein cholesterolsevere ulcerative colitistotal cholesteroltriglycerideulcerative colitis |
| spellingShingle | Zhu L Tian L Li S Huo L Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis International Journal of General Medicine erythrocyte sedimentation rate high-density lipoprotein cholesterol lipid levels low-density lipoprotein cholesterol non-high-density lipoprotein cholesterol severe ulcerative colitis total cholesterol triglyceride ulcerative colitis |
| title | Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis |
| title_full | Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis |
| title_fullStr | Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis |
| title_full_unstemmed | Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis |
| title_short | Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis |
| title_sort | blood lipid levels and their value as markers of disease activity in severe ulcerative colitis |
| topic | erythrocyte sedimentation rate high-density lipoprotein cholesterol lipid levels low-density lipoprotein cholesterol non-high-density lipoprotein cholesterol severe ulcerative colitis total cholesterol triglyceride ulcerative colitis |
| url | https://www.dovepress.com/blood-lipid-levels-and-their-value-as-markers-of-disease-activity-in-s-peer-reviewed-fulltext-article-IJGM |
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