Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma

Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma

Abstract Background Tyroservatide (YSV), a bioactive tripeptide, holds potential as an anti-tumor agent. However, its specific effects on oral squamous cell carcinoma (OSCC) have not been elucidated. This study aims to investigate the inhibitory effects of YSV on OSCC and explore the underlying mole...

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Bibliographic Details
Main Authors: Lin Qiu, Qian Gao, Yiheng Liao, Xinxin Li, Cuiying Li
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Translational Medicine
Subjects:
Oral squamous cell carcinoma
Tyroservatide
Proliferation
Cell cycle
Apoptosis
PTEN/PI3K/AKT signaling pathway
Online Access:https://doi.org/10.1186/s12967-025-06169-z
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https://doi.org/10.1186/s12967-025-06169-z

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