Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India
Background: Coronavirus disease 2019 (Covid-19) is a novel disease caused by coronavirus-2 that causes severe acute respiratory syndrome (SARS-CoV-2). Although it primarily affects the respiratory system, the virus may also target the pancreas. It was suggested that upregulation of angiotensin-conv...
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Indonesian Society for Biochemistry and Molecular Biology
2023-10-01
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| Series: | Acta Biochimica Indonesiana |
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| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/141 |
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| author | Nabeela Usmani Mukhtar Ahmad Saba Khan Mohammad Mustufa Khan Haseeb Ahsan Sadaf Parveen Roshan Alam |
| author_facet | Nabeela Usmani Mukhtar Ahmad Saba Khan Mohammad Mustufa Khan Haseeb Ahsan Sadaf Parveen Roshan Alam |
| author_sort | Nabeela Usmani |
| collection | DOAJ |
| description |
Background: Coronavirus disease 2019 (Covid-19) is a novel disease caused by coronavirus-2 that causes severe acute respiratory syndrome (SARS-CoV-2). Although it primarily affects the respiratory system, the virus may also target the pancreas. It was suggested that upregulation of angiotensin-converting enzyme II (ACE-II) cell receptors or inflammatory cytokines play a major role in predisposing pancreatic injury in SARS-CoV-2 patients. Our aim was to conduct a critical evaluation of in order to provide an insight into the possibility of pancreatic injury.
Methods: A case control study was conducted in the Department of Biochemistry IIMS&R, Integral University, Lucknow. Two groups of subjects (70 adults consisting of 35 Covid-19 survivors and 35 controls) aged between 35 to 70 years were selected for the study with mild to moderate Covid-19 diagnosed using RT-PCR/rapid antigen test and a control group of healthy individuals without history of Covid-19. The serum amylase was determined by the direct substrate method and serum lipase by the turbidimetric UV method using a semi-autoanalyzer.
Results: The study showed that the serum amylase (p=0.023) and lipase (p=0.002) levels were significantly elevated in Covid-19 patients compared to the control subjects. The findings indicated that Covid-19 patients had a substantially higher mean serum amylase and lipase levels than the control subjects.
Conclusions: The Covid-19 patients are prone to pancreatic injury.
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| format | Article |
| id | doaj-art-890e489a1f504a128546cdc485ff08a0 |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-890e489a1f504a128546cdc485ff08a02025-02-08T03:05:53ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222023-10-016110.32889/actabioina.141Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, IndiaNabeela Usmani0Mukhtar Ahmad1Saba Khan2Mohammad Mustufa Khan3Haseeb Ahsan4Sadaf Parveen5Roshan Alam6Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, IndiaDepartment of Medicine, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, IndiaDepartment of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, IndiaDepartment of Basic Medical Sciences, Integral Institute of Allied Health Sciences and Research, Integral University, Lucknow, IndiaDepartment of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, IndiaDepartment of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, IndiaDepartment of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, India Background: Coronavirus disease 2019 (Covid-19) is a novel disease caused by coronavirus-2 that causes severe acute respiratory syndrome (SARS-CoV-2). Although it primarily affects the respiratory system, the virus may also target the pancreas. It was suggested that upregulation of angiotensin-converting enzyme II (ACE-II) cell receptors or inflammatory cytokines play a major role in predisposing pancreatic injury in SARS-CoV-2 patients. Our aim was to conduct a critical evaluation of in order to provide an insight into the possibility of pancreatic injury. Methods: A case control study was conducted in the Department of Biochemistry IIMS&R, Integral University, Lucknow. Two groups of subjects (70 adults consisting of 35 Covid-19 survivors and 35 controls) aged between 35 to 70 years were selected for the study with mild to moderate Covid-19 diagnosed using RT-PCR/rapid antigen test and a control group of healthy individuals without history of Covid-19. The serum amylase was determined by the direct substrate method and serum lipase by the turbidimetric UV method using a semi-autoanalyzer. Results: The study showed that the serum amylase (p=0.023) and lipase (p=0.002) levels were significantly elevated in Covid-19 patients compared to the control subjects. The findings indicated that Covid-19 patients had a substantially higher mean serum amylase and lipase levels than the control subjects. Conclusions: The Covid-19 patients are prone to pancreatic injury. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/141Coronavirus disease 2019SARS-CoV-2serum lipaseserum amylaseCovid-19 |
| spellingShingle | Nabeela Usmani Mukhtar Ahmad Saba Khan Mohammad Mustufa Khan Haseeb Ahsan Sadaf Parveen Roshan Alam Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India Acta Biochimica Indonesiana Coronavirus disease 2019 SARS-CoV-2 serum lipase serum amylase Covid-19 |
| title | Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India |
| title_full | Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India |
| title_fullStr | Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India |
| title_full_unstemmed | Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India |
| title_short | Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India |
| title_sort | evaluation of serum amylase and lipase in diagnosed covid 19 survivors in a north indian hospital lucknow india |
| topic | Coronavirus disease 2019 SARS-CoV-2 serum lipase serum amylase Covid-19 |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/141 |
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