Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients
Purpose: To investigate the differences in brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis (ALS-L and ALS-B, respectively) patients using resting-state functional MRI (rs-fMRI) with amplitude of low-frequency fluctuation (ALFF) and regional homogen...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000413 |
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| author | Si-Jie Chen Qing-Yang Li Jiang Zhou Qian Wu Yu Zhang Qian-Qian Zhang Hao Hu Xiao-Quan Xu Fei-Yun Wu Qi Niu |
| author_facet | Si-Jie Chen Qing-Yang Li Jiang Zhou Qian Wu Yu Zhang Qian-Qian Zhang Hao Hu Xiao-Quan Xu Fei-Yun Wu Qi Niu |
| author_sort | Si-Jie Chen |
| collection | DOAJ |
| description | Purpose: To investigate the differences in brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis (ALS-L and ALS-B, respectively) patients using resting-state functional MRI (rs-fMRI) with amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo). Materials and methods: The rs-fMRI data were collected from 41 ALS patients (11 ALS-B and 30 ALS-L) and 25 healthy controls (HC). ALFF and ReHo values were calculated, and group differences were assessed using one-way ANCOVA and two-sample t-tests. Correlation analyses with clinical measures were conducted. Support vector machine (SVM) analysis was performed to distinguish ALS subtypes. Results: Compared with ALS-L, ALS-B showed increased ALFF values in the right gyrus rectus/ orbital part of right middle frontal gyrus, orbital part of left middle frontal gyrus and left dorsolateral superior frontal gyrus/ left medial superior frontal gyrus and decreased ALFF values in the left superior occipital gyrus (FDR-corrected, P < 0.05). Both ALS subtypes demonstrated distinct ALFF alterations compared to HC. Differences in ReHo values were only found between ALS-B and HC. Correlation analyses revealed associations between ALFF in specific brain regions and ALS clinical scores. SVM analysis achieved an accuracy of 90.2 %, with an AUC of 0.909 in differentiating ALS-B and ALS-L. Conclusion: ALS-B and ALS-L patients had distinct alterations in brain spontaneous neural activity, which could serve as potential biomarkers for accurately distinguishing these two subtypes. Our findings offer a new insight into the neural mechanism of ALS, underscoring the importance of personalized diagnostic approaches for this complex neurological disorder. |
| format | Article |
| id | doaj-art-98ee3ae765d444949486000674f6abe4 |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-98ee3ae765d444949486000674f6abe42025-02-07T04:46:48ZengElsevierBrain Research Bulletin1873-27472025-02-01221111229Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patientsSi-Jie Chen0Qing-Yang Li1Jiang Zhou2Qian Wu3Yu Zhang4Qian-Qian Zhang5Hao Hu6Xiao-Quan Xu7Fei-Yun Wu8Qi Niu9Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Correspondence to: Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Rd., Nanjing, China.Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Correspondence to: Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Rd., Nanjing, China.Purpose: To investigate the differences in brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis (ALS-L and ALS-B, respectively) patients using resting-state functional MRI (rs-fMRI) with amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo). Materials and methods: The rs-fMRI data were collected from 41 ALS patients (11 ALS-B and 30 ALS-L) and 25 healthy controls (HC). ALFF and ReHo values were calculated, and group differences were assessed using one-way ANCOVA and two-sample t-tests. Correlation analyses with clinical measures were conducted. Support vector machine (SVM) analysis was performed to distinguish ALS subtypes. Results: Compared with ALS-L, ALS-B showed increased ALFF values in the right gyrus rectus/ orbital part of right middle frontal gyrus, orbital part of left middle frontal gyrus and left dorsolateral superior frontal gyrus/ left medial superior frontal gyrus and decreased ALFF values in the left superior occipital gyrus (FDR-corrected, P < 0.05). Both ALS subtypes demonstrated distinct ALFF alterations compared to HC. Differences in ReHo values were only found between ALS-B and HC. Correlation analyses revealed associations between ALFF in specific brain regions and ALS clinical scores. SVM analysis achieved an accuracy of 90.2 %, with an AUC of 0.909 in differentiating ALS-B and ALS-L. Conclusion: ALS-B and ALS-L patients had distinct alterations in brain spontaneous neural activity, which could serve as potential biomarkers for accurately distinguishing these two subtypes. Our findings offer a new insight into the neural mechanism of ALS, underscoring the importance of personalized diagnostic approaches for this complex neurological disorder.http://www.sciencedirect.com/science/article/pii/S0361923025000413Amyotrophic lateral sclerosisBulbar-onsetLimb-onsetResting-state functional magnetic resonance imagingAmplitude of low-frequency fluctuationRegional homogeneity |
| spellingShingle | Si-Jie Chen Qing-Yang Li Jiang Zhou Qian Wu Yu Zhang Qian-Qian Zhang Hao Hu Xiao-Quan Xu Fei-Yun Wu Qi Niu Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients Brain Research Bulletin Amyotrophic lateral sclerosis Bulbar-onset Limb-onset Resting-state functional magnetic resonance imaging Amplitude of low-frequency fluctuation Regional homogeneity |
| title | Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients |
| title_full | Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients |
| title_fullStr | Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients |
| title_full_unstemmed | Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients |
| title_short | Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients |
| title_sort | differed brain spontaneous neural activity between limb onset and bulbar onset amyotrophic lateral sclerosis patients |
| topic | Amyotrophic lateral sclerosis Bulbar-onset Limb-onset Resting-state functional magnetic resonance imaging Amplitude of low-frequency fluctuation Regional homogeneity |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000413 |
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