The role of ESRP1 in solid tumor development through the regulation of CD44 splicing and EMT processes
According to the World Health Organization’s statistics, cancer is the second leading cause of death worldwide, following cardiovascular diseases. Despite significant progress in the field of cancer treatment in recent years, cancer remains one of the main factors shortening human life expectancy. T...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1451130/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856607978586112 |
|---|---|
| author | Lili Wang Min Zhang Lei Ke Zhao Xiaohan Yuan Houyu Zhao Yanting Liu Yinghua Ji Ping Lu |
| author_facet | Lili Wang Min Zhang Lei Ke Zhao Xiaohan Yuan Houyu Zhao Yanting Liu Yinghua Ji Ping Lu |
| author_sort | Lili Wang |
| collection | DOAJ |
| description | According to the World Health Organization’s statistics, cancer is the second leading cause of death worldwide, following cardiovascular diseases. Despite significant progress in the field of cancer treatment in recent years, cancer remains one of the main factors shortening human life expectancy. The field of cancer research is increasingly focusing on the role of tumor-related oncogenes and heterogeneous proteins in the development of cancer. Studies indicate that there is a close connection between solid tumors and epithelial splicing regulatory protein 1 (ESRP1). ESRP1 is a key intracellular molecule that plays a crucial role in cell growth and differentiation. As an emerging biomarker, ESRP1 has a decisive impact on the formation and development of solid tumors by regulating the alternative splicing of CD44 and the epithelial-mesenchymal transition (EMT) process. Research shows that abnormal expression of ESRP1 is closely related to the formation and development of various solid tumors, including breast cancer, lung cancer, stomach cancer, and others, and is closely associated with the invasiveness, metastasis, and poor prognosis of tumors. Therefore, given ESRP1’s critical role in cancer development, it is gradually becoming a potential biomarker and therapeutic target. This review primarily discusses the molecular mechanisms of ESRP1 in regulating cancer metastasis, particularly its regulatory effects on CD44 splicing and the EMT process. These research findings provide new targets for cancer treatment, aiming to bring more precise diagnosis and more effective treatment strategies to patients. |
| format | Article |
| id | doaj-art-9c1e135db8b14a328987f0efb33d6f68 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-9c1e135db8b14a328987f0efb33d6f682025-02-12T07:26:13ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.14511301451130The role of ESRP1 in solid tumor development through the regulation of CD44 splicing and EMT processesLili WangMin ZhangLei Ke ZhaoXiaohan YuanHouyu ZhaoYanting LiuYinghua JiPing LuAccording to the World Health Organization’s statistics, cancer is the second leading cause of death worldwide, following cardiovascular diseases. Despite significant progress in the field of cancer treatment in recent years, cancer remains one of the main factors shortening human life expectancy. The field of cancer research is increasingly focusing on the role of tumor-related oncogenes and heterogeneous proteins in the development of cancer. Studies indicate that there is a close connection between solid tumors and epithelial splicing regulatory protein 1 (ESRP1). ESRP1 is a key intracellular molecule that plays a crucial role in cell growth and differentiation. As an emerging biomarker, ESRP1 has a decisive impact on the formation and development of solid tumors by regulating the alternative splicing of CD44 and the epithelial-mesenchymal transition (EMT) process. Research shows that abnormal expression of ESRP1 is closely related to the formation and development of various solid tumors, including breast cancer, lung cancer, stomach cancer, and others, and is closely associated with the invasiveness, metastasis, and poor prognosis of tumors. Therefore, given ESRP1’s critical role in cancer development, it is gradually becoming a potential biomarker and therapeutic target. This review primarily discusses the molecular mechanisms of ESRP1 in regulating cancer metastasis, particularly its regulatory effects on CD44 splicing and the EMT process. These research findings provide new targets for cancer treatment, aiming to bring more precise diagnosis and more effective treatment strategies to patients.https://www.frontiersin.org/articles/10.3389/fonc.2025.1451130/fullESRP1CD44EMTalternative splicingsolid tumor |
| spellingShingle | Lili Wang Min Zhang Lei Ke Zhao Xiaohan Yuan Houyu Zhao Yanting Liu Yinghua Ji Ping Lu The role of ESRP1 in solid tumor development through the regulation of CD44 splicing and EMT processes Frontiers in Oncology ESRP1 CD44 EMT alternative splicing solid tumor |
| title | The role of ESRP1 in solid tumor development through the regulation of CD44 splicing and EMT processes |
| title_full | The role of ESRP1 in solid tumor development through the regulation of CD44 splicing and EMT processes |
| title_fullStr | The role of ESRP1 in solid tumor development through the regulation of CD44 splicing and EMT processes |
| title_full_unstemmed | The role of ESRP1 in solid tumor development through the regulation of CD44 splicing and EMT processes |
| title_short | The role of ESRP1 in solid tumor development through the regulation of CD44 splicing and EMT processes |
| title_sort | role of esrp1 in solid tumor development through the regulation of cd44 splicing and emt processes |
| topic | ESRP1 CD44 EMT alternative splicing solid tumor |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1451130/full |
| work_keys_str_mv | AT liliwang theroleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT minzhang theroleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT leikezhao theroleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT xiaohanyuan theroleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT houyuzhao theroleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT yantingliu theroleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT yinghuaji theroleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT pinglu theroleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT liliwang roleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT minzhang roleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT leikezhao roleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT xiaohanyuan roleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT houyuzhao roleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT yantingliu roleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT yinghuaji roleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses AT pinglu roleofesrp1insolidtumordevelopmentthroughtheregulationofcd44splicingandemtprocesses |