Methods to address functional unblinding of raters in CNS trials

Abstract Treatment-emergent adverse events (TEAEs) associated with the unique properties of a pharmaceutical product may functionally unblind clinician ratings, obscure true medication effects, and affect confidence about clinical trial results. Central nervous system studies are particularly suscep...

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Bibliographic Details
Main Authors: Steven D. Targum, William P. Horan, Vicki G. Davis, Alan Breier, Stephen K. Brannan
Format: Article
Language:English
Published: Nature Publishing Group 2025-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03262-1
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