Establishment of a bat lung organoid culture model for studying bat-derived infectious diseases

Establishment of a bat lung organoid culture model for studying bat-derived infectious diseases

Abstract Bat is considered a natural reservoir of various important pathogens, including severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2, Ebola virus, and Nipah virus. To study these viruses’ pathogenicity and proliferation efficacy and viral tolerance mechanisms in bats, bat-de...

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Main Authors: Mohamed Elbadawy, Nagisa Saito, Yuki Kato, Kimika Hayashi, Amira Abugomaa, Mio Kobayashi, Toshinori Yoshida, Makoto Shibutani, Masahiro Kaneda, Hideyuki Yamawaki, Kazuaki Sasaki, Tatsuya Usui, Tsutomu Omatsu
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Bat
Rousettus leschenaultii
Lung organoid
ACE2
TMPRSS2
Alveolar type 2 cells
Online Access:https://doi.org/10.1038/s41598-025-88621-0
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https://doi.org/10.1038/s41598-025-88621-0

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