Development of an automated method for in-house production of sodium 18F-fluoride for injection: process validation as a step toward routine clinical application

Development of an automated method for in-house production of sodium 18F-fluoride for injection: process validation as a step toward routine clinical application

Abstract Background Sodium 18F-fluoride for injection can be easily cyclotron-produced and purified, as a simple inorganic salt, by adsorption/desorption onto an anion-exchange cartridge and then dispensed for clinical use. Since the clinical demand for this radiopharmaceutical is constantly increas...

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Main Authors: Marija Atanasova Lazareva, Maja Chochevska, Katerina Kolevska, Maja Velickovska, Filip Jolevski, Paulina Apostolova, Ana Ugrinska, Emilija Janevik-Ivanovska
Format: Article
Language:English
Published: SpringerOpen 2025-02-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
In-house production
[18F]NaF
Cost-effective method
Residual activity
Validation
Online Access:https://doi.org/10.1186/s41181-025-00329-8
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https://doi.org/10.1186/s41181-025-00329-8

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