How spinal GABAergic circuits modulate cerebral processing of postsurgical pain

How spinal GABAergic circuits modulate cerebral processing of postsurgical pain

Post-surgical pain affects millions each year, hindering recovery and quality of life. Surgical procedures cause tissue damage and inflammation, leading to peripheral and central sensitization, resulting in pain at rest or mechanical and heat hyperalgesia. In a rat model for post-surgical pain, spin...

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Bibliographic Details
Main Authors: Bruno Pradier, Daniel Segelcke, Nathalie Just, Mirjam Augustin, Nina Nagelmann, Cornelius Faber, Esther Pogatzki-Zahn
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Pharmacological Research
Subjects:
BOLD fMRI and resting-state and mechanical stimulation
Brain network and graph theory
Incision model and post-operative pain
Non-evoked pain and evoked pain
Intrathecal and muscimol and bicuculline
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825000349
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