Acid sphingomyelinase modulates anxiety-like behavior likely through toll-like receptor signaling pathway

Abstract Recent studies have shown that abnormal activity of acid sphingomyelinase (Asm) has been associated with a range of psychiatric disorders including schizophrenia and depression. However, the role of Asm in the regulation of anxiety remains unclear. In the present study, we employed Asm-knoc...

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Bibliographic Details
Main Authors: Huiqi Yuan, Yanan Xu, Hailun Jiang, Meizhu Jiang, Luofei Zhang, Shifeng Wei, Cao Li, Zhigang Zhao
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Brain
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Online Access:https://doi.org/10.1186/s13041-025-01178-x
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