Disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone, an evidence of children in a rural area, South China
Neonicotinoids exposure was found to induce thyroid dysfunction. However, there lack of direct evidence between neonicotinoids exposure and thyroid hormone (TH) disruption in population study, especially in children, which limits the understanding on their health hazard. To fill this knowledge gap,...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325001241 |
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| author | Ling-Chuan Guo Pan Zhu Chunyan Gui Jing Deng Yanhong Gao Chaoyang Long Han Zhang Zhanlu Lv Shengbing Yu |
| author_facet | Ling-Chuan Guo Pan Zhu Chunyan Gui Jing Deng Yanhong Gao Chaoyang Long Han Zhang Zhanlu Lv Shengbing Yu |
| author_sort | Ling-Chuan Guo |
| collection | DOAJ |
| description | Neonicotinoids exposure was found to induce thyroid dysfunction. However, there lack of direct evidence between neonicotinoids exposure and thyroid hormone (TH) disruption in population study, especially in children, which limits the understanding on their health hazard. To fill this knowledge gap, we conducted a cross-sectional study on children of a rural area in South China (n = 88), and analyzed urinary ten neonicotinoids (including metabolites), serum TH, thyroxine-binding globulin (TBG), and thyroid stimulating hormone (TSH) levels. Based on linear regression, generalized additive model, and Bayesian kernel machine regression, neonicotinoids levels were found to be correlated with TH, TBG, and TSH levels, with stronger effects for metabolites than parent compounds in most cases. Mixture exposure of neonicotinoids had significantly positive effect on free triiodothyronine (T3). N-desmethyl-acetamiprid (N-dm-ACE) was negatively associated with T3 for female, which corresponded to much lower T3 levels for female than for male. Also, N-dm-ACE was found to non-monotonic associated with free thyroxine for male. Some neonicotinoids had interactive effects with lead and cadmium on TH disruption. The results provide an evidence on TH disruption of neonicotinoids in children, and highlight the need to explore TH disruption of neonicotinoids and safeguard the health of children. |
| format | Article |
| id | doaj-art-bdde41207feb4618af656a29304affbf |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-bdde41207feb4618af656a29304affbf2025-02-12T05:30:21ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117788Disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone, an evidence of children in a rural area, South ChinaLing-Chuan Guo0Pan Zhu1Chunyan Gui2Jing Deng3Yanhong Gao4Chaoyang Long5Han Zhang6Zhanlu Lv7Shengbing Yu8State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; Corresponding authors.Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; Corresponding authors.Neonicotinoids exposure was found to induce thyroid dysfunction. However, there lack of direct evidence between neonicotinoids exposure and thyroid hormone (TH) disruption in population study, especially in children, which limits the understanding on their health hazard. To fill this knowledge gap, we conducted a cross-sectional study on children of a rural area in South China (n = 88), and analyzed urinary ten neonicotinoids (including metabolites), serum TH, thyroxine-binding globulin (TBG), and thyroid stimulating hormone (TSH) levels. Based on linear regression, generalized additive model, and Bayesian kernel machine regression, neonicotinoids levels were found to be correlated with TH, TBG, and TSH levels, with stronger effects for metabolites than parent compounds in most cases. Mixture exposure of neonicotinoids had significantly positive effect on free triiodothyronine (T3). N-desmethyl-acetamiprid (N-dm-ACE) was negatively associated with T3 for female, which corresponded to much lower T3 levels for female than for male. Also, N-dm-ACE was found to non-monotonic associated with free thyroxine for male. Some neonicotinoids had interactive effects with lead and cadmium on TH disruption. The results provide an evidence on TH disruption of neonicotinoids in children, and highlight the need to explore TH disruption of neonicotinoids and safeguard the health of children.http://www.sciencedirect.com/science/article/pii/S0147651325001241NeonicotinoidsMetabolitesThyroid hormoneMixture exposureSex-specificInteraction |
| spellingShingle | Ling-Chuan Guo Pan Zhu Chunyan Gui Jing Deng Yanhong Gao Chaoyang Long Han Zhang Zhanlu Lv Shengbing Yu Disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone, an evidence of children in a rural area, South China Ecotoxicology and Environmental Safety Neonicotinoids Metabolites Thyroid hormone Mixture exposure Sex-specific Interaction |
| title | Disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone, an evidence of children in a rural area, South China |
| title_full | Disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone, an evidence of children in a rural area, South China |
| title_fullStr | Disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone, an evidence of children in a rural area, South China |
| title_full_unstemmed | Disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone, an evidence of children in a rural area, South China |
| title_short | Disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone, an evidence of children in a rural area, South China |
| title_sort | disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone an evidence of children in a rural area south china |
| topic | Neonicotinoids Metabolites Thyroid hormone Mixture exposure Sex-specific Interaction |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325001241 |
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