Cross-transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep
Wild and domestic ungulates can be infected with the same species of gastrointestinal parasitic nematodes. These parasites have free-living stages in the environment that contribute to the ease of transmission among different host species. In addition, gastrointestinal nematodes have developed resis...
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2024-10-01
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| Online Access: | https://peercommunityjournal.org/articles/10.24072/pcjournal.477/ |
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| author | Beaumelle, Camille Toïgo, Carole Papet, Rodolphe Benabed, Slimania Beurier, Mathieu Bordes, Léa Brignone, Anaïs Curt-Grand-Gaudin, Nadine Garel, Mathieu Ginot, Justine Jacquiet, Philippe Miquel, Christian Poirel, Marie-Thérèse Serafino, Anna Vannard, Eric Bourgoin, Gilles Yannic, Glenn |
| author_facet | Beaumelle, Camille Toïgo, Carole Papet, Rodolphe Benabed, Slimania Beurier, Mathieu Bordes, Léa Brignone, Anaïs Curt-Grand-Gaudin, Nadine Garel, Mathieu Ginot, Justine Jacquiet, Philippe Miquel, Christian Poirel, Marie-Thérèse Serafino, Anna Vannard, Eric Bourgoin, Gilles Yannic, Glenn |
| author_sort | Beaumelle, Camille |
| collection | DOAJ |
| description | Wild and domestic ungulates can be infected with the same species of gastrointestinal parasitic nematodes. These parasites have free-living stages in the environment that contribute to the ease of transmission among different host species. In addition, gastrointestinal nematodes have developed resistance to anthelmintics which is now considered a major problem for the livestock sector. In a context where wild and domestic ungulates share the same pastures, the maintenance and circulation of resistant gastrointestinal nematodes between species have rarely been explored. In the European Alps, domestic sheep are driven to high-altitude summer pastures and live in sympatry with wild ungulates for several months each year. In this study, we investigated the nemabiome of domestic sheep and Alpine ibex, Capra ibex, in three different areas of the French Alps to evaluate parasite circulation between the two host species. The Alpine ibex is a protected mountain ungulate that is phylogenetically related to sheep and hosts nematode species common to sheep. Using internal transcribed spacer 2 (ITS-2) nemabiome metabarcoding, we found sheep and ibex share similar gastrointestinal nematodes, except for a few species such as Marshallagia marshalli and Trichostrongylus axei. This suggests that the long-term co-occurrence of sheep and ibex on mountain pastures has promoted the exchange of gastrointestinal nematodes between the two hosts. Based on the sequencing of the isotype 1 of the beta tubulin gene, associated with benzimidazole resistance, we found resistant nematodes in all sheep flocks and in all ibex populations. Our results demonstrated that ibex can host and shed resistant strains before transhumant sheep arrive on pastures, and thus could act as a refuge or even contribute to maintaining resistant gastrointestinal nematodes. The relative role of ibex in the maintenance and circulation of resistant strains in sheep remain to be determined. |
| format | Article |
| id | doaj-art-bfebfa8d25084d20be41760dfef937e4 |
| institution | Kabale University |
| issn | 2804-3871 |
| language | English |
| publishDate | 2024-10-01 |
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| series | Peer Community Journal |
| spelling | doaj-art-bfebfa8d25084d20be41760dfef937e42025-02-07T10:17:17ZengPeer Community InPeer Community Journal2804-38712024-10-01410.24072/pcjournal.47710.24072/pcjournal.477Cross-transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep Beaumelle, Camille0Toïgo, Carole1Papet, Rodolphe2Benabed, Slimania3Beurier, Mathieu4Bordes, Léa5Brignone, Anaïs6Curt-Grand-Gaudin, Nadine7Garel, Mathieu8Ginot, Justine9Jacquiet, Philippe10Miquel, Christian11Poirel, Marie-Thérèse12Serafino, Anna13Vannard, Eric14Bourgoin, Gilles15Yannic, Glenn16Université de Lyon, Université Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR 5558, Villeurbanne, France; Université de Lyon, VetAgro Sup, Campus Vétérinaire de Lyon, Marcy l’Etoile, France; Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS, LECA, Grenoble, FranceOffice Français de la Biodiversité, Service Anthropisation et Fonctionnement des Ecosystèmes Terrestres, Gières, FranceParc national des Écrins, Secteur du Champsaur-Valgaudemar, Saint Jean Saint Nicolas, FranceUniversité de Lyon, Université Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR 5558, Villeurbanne, France; Université de Lyon, VetAgro Sup, Campus Vétérinaire de Lyon, Marcy l’Etoile, FranceOffice Français de la Biodiversité, Service Anthropisation et Fonctionnement des Ecosystèmes Terrestres, Gières, FranceUniversité de Toulouse, UMT Pilotage de la Santé des Ruminants, Ecole Nationale Vétérinaire de Toulouse, FranceOffice Français de la Biodiversité, Unité Ongulés Sauvages, Gières, FranceUniversité Grenoble Alpes, Université Savoie Mont Blanc, CNRS, LECA, Grenoble, FranceOffice Français de la Biodiversité, Service Anthropisation et Fonctionnement des Ecosystèmes Terrestres, Gières, FranceUniversité de Lyon, VetAgro Sup, Campus Vétérinaire de Lyon, Marcy l’Etoile, FranceUniversité de Toulouse, UMT Pilotage de la Santé des Ruminants, Ecole Nationale Vétérinaire de Toulouse, FranceUniversité Grenoble Alpes, Université Savoie Mont Blanc, CNRS, LECA, Grenoble, FranceUniversité de Lyon, Université Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR 5558, Villeurbanne, France; Université de Lyon, VetAgro Sup, Campus Vétérinaire de Lyon, Marcy l’Etoile, FranceUniversité de Lyon, VetAgro Sup, Campus Vétérinaire de Lyon, Marcy l’Etoile, FranceParc national des Écrins, Secteur du Briançonnais, Briançon, FranceUniversité de Lyon, Université Lyon 1, CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR 5558, Villeurbanne, France; Université de Lyon, VetAgro Sup, Campus Vétérinaire de Lyon, Marcy l’Etoile, FranceUniversité Grenoble Alpes, Université Savoie Mont Blanc, CNRS, LECA, Grenoble, FranceWild and domestic ungulates can be infected with the same species of gastrointestinal parasitic nematodes. These parasites have free-living stages in the environment that contribute to the ease of transmission among different host species. In addition, gastrointestinal nematodes have developed resistance to anthelmintics which is now considered a major problem for the livestock sector. In a context where wild and domestic ungulates share the same pastures, the maintenance and circulation of resistant gastrointestinal nematodes between species have rarely been explored. In the European Alps, domestic sheep are driven to high-altitude summer pastures and live in sympatry with wild ungulates for several months each year. In this study, we investigated the nemabiome of domestic sheep and Alpine ibex, Capra ibex, in three different areas of the French Alps to evaluate parasite circulation between the two host species. The Alpine ibex is a protected mountain ungulate that is phylogenetically related to sheep and hosts nematode species common to sheep. Using internal transcribed spacer 2 (ITS-2) nemabiome metabarcoding, we found sheep and ibex share similar gastrointestinal nematodes, except for a few species such as Marshallagia marshalli and Trichostrongylus axei. This suggests that the long-term co-occurrence of sheep and ibex on mountain pastures has promoted the exchange of gastrointestinal nematodes between the two hosts. Based on the sequencing of the isotype 1 of the beta tubulin gene, associated with benzimidazole resistance, we found resistant nematodes in all sheep flocks and in all ibex populations. Our results demonstrated that ibex can host and shed resistant strains before transhumant sheep arrive on pastures, and thus could act as a refuge or even contribute to maintaining resistant gastrointestinal nematodes. The relative role of ibex in the maintenance and circulation of resistant strains in sheep remain to be determined.https://peercommunityjournal.org/articles/10.24072/pcjournal.477/ITS-2 rDNA, benzimidazole resistance, β-tubulin isotype 1, livestock, nemabiome metabarcoding, wild ungulates, transhumant sheep, Alpine ibex |
| spellingShingle | Beaumelle, Camille Toïgo, Carole Papet, Rodolphe Benabed, Slimania Beurier, Mathieu Bordes, Léa Brignone, Anaïs Curt-Grand-Gaudin, Nadine Garel, Mathieu Ginot, Justine Jacquiet, Philippe Miquel, Christian Poirel, Marie-Thérèse Serafino, Anna Vannard, Eric Bourgoin, Gilles Yannic, Glenn Cross-transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep Peer Community Journal ITS-2 rDNA, benzimidazole resistance, β-tubulin isotype 1, livestock, nemabiome metabarcoding, wild ungulates, transhumant sheep, Alpine ibex |
| title | Cross-transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep
|
| title_full | Cross-transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep
|
| title_fullStr | Cross-transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep
|
| title_full_unstemmed | Cross-transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep
|
| title_short | Cross-transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep
|
| title_sort | cross transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep |
| topic | ITS-2 rDNA, benzimidazole resistance, β-tubulin isotype 1, livestock, nemabiome metabarcoding, wild ungulates, transhumant sheep, Alpine ibex |
| url | https://peercommunityjournal.org/articles/10.24072/pcjournal.477/ |
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