Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus

Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus

Abstract Background The rapid emergence of multiple drug-resistant (MDR) bacterial pathogens and the lack of a novel antibiotic pipeline pose a serious threat to global healthcare. The limited number of established targets further restricts the identification of novel antibiotics to treat life-threa...

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Main Authors: Maria Sultan, Maria Razzaq, Joohyun Lee, Shreyasi Das, Shrute Kannappan, Vinod Kumar Subramani, Wanki Yoo, Truc Kim, Hye-Ra Lee, Akhilesh K. Chaurasia, Kyeong Kyu Kim
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Biomedical Science
Subjects:
S. aureus USA300
G-quadruplex
G4 ligands
N-methyl mesoporphyrin IX (NMM)
Division cell wall
dcw cluster
Online Access:https://doi.org/10.1186/s12929-024-01109-3
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https://doi.org/10.1186/s12929-024-01109-3

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