Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption

Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption

Abstract Background Breast Cancer (BC) is the most common type of cancer in women around the world and 70% of cases are hormone-receptor positive (HR+). In 40% of cases, a key mechanism of endocrine resistance to the standard first line is a mutation of the ligand-binding domain (LBD) of Estrogen Re...

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Main Authors: Morgane Lopez, Laurie Spehner, Fabrice André, Julien Viot, Evan Seffar, Amélie Marguier, Elsa Curtit, Guillaume Meynard, Erion Dobi, Sylvain Ladoire, Romain Boidot, Romain Loyon, Valentin Derangere, François-Clément Bidard, Christophe Borg, Laura Mansi, Marie Kroemer
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Breast Cancer Research
Subjects:
Hormone-receptor positive breast cancer
ESR1 mutation
Specific immune responses
Neoantigen
T cell
Online Access:https://doi.org/10.1186/s13058-025-01962-6
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https://doi.org/10.1186/s13058-025-01962-6

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