Accelerating biopharmaceutical cell line selection with label-free multimodal nonlinear optical microscopy and machine learning

Accelerating biopharmaceutical cell line selection with label-free multimodal nonlinear optical microscopy and machine learning

Abstract The selection of high-performing cell lines is crucial for biopharmaceutical production but is often time-consuming and labor-intensive. We investigated label-free multimodal nonlinear optical microscopy for non-perturbative profiling of biopharmaceutical cell lines based on their intrinsic...

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Main Authors: Jindou Shi, Alexander Ho, Corey E. Snyder, Eric J. Chaney, Janet E. Sorrells, Aneesh Alex, Remben Talaban, Darold R. Spillman, Marina Marjanovic, Minh Doan, Gary Finka, Steve R. Hood, Stephen A. Boppart
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07596-w
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https://doi.org/10.1038/s42003-025-07596-w

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