Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution

Abstract During human evolution, some genes were lost or silenced from the genome of hominins. These missing genes might be the key to the evolution of humans’ unique cognitive skills. An inactivation mutation in CMP-N-acetylneuraminic acid hydroxylase (CMAH) was the result of natural selection. The...

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Bibliographic Details
Main Authors: Yuxin Liu, Jinhong Li, Qicai Liu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Inflammation and Regeneration
Subjects:
Online Access:https://doi.org/10.1186/s41232-025-00368-3
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