Candida dubliniensis breast implant infection in a lung transplant recipient

This report details the case of a lung transplant recipient with a remote history of breast cancer and breast reconstruction with implants, who received lengthy antifungal therapy for a post-transplant donor-transmitted Candida dubliniensis empyema. Despite this, she presented months later with a pr...

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Main Authors: Ashley Barnes, MD, Kristen Broderick, MD, Errol Bush, MD, Jonathan Orens, MD, Melanie Marashly, CRNP, Shmuel Shoham, MD, Robin Avery, MD
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:JHLT Open
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Online Access:http://www.sciencedirect.com/science/article/pii/S2950133424001435
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author Ashley Barnes, MD
Kristen Broderick, MD
Errol Bush, MD
Jonathan Orens, MD
Melanie Marashly, CRNP
Shmuel Shoham, MD
Robin Avery, MD
author_facet Ashley Barnes, MD
Kristen Broderick, MD
Errol Bush, MD
Jonathan Orens, MD
Melanie Marashly, CRNP
Shmuel Shoham, MD
Robin Avery, MD
author_sort Ashley Barnes, MD
collection DOAJ
description This report details the case of a lung transplant recipient with a remote history of breast cancer and breast reconstruction with implants, who received lengthy antifungal therapy for a post-transplant donor-transmitted Candida dubliniensis empyema. Despite this, she presented months later with a progressive infection of bilateral breast implants, which also proved to be due to Candida dubliniensis. Few cases of breast implant infection after lung transplant have been published. It is possible that biofilm created a barrier to penetration of antifungals, which were able to suppress but not eradicate infection. This case highlights the importance of deep operative cultures for diagnosis and management of infections of this type.
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institution Kabale University
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language English
publishDate 2025-02-01
publisher Elsevier
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series JHLT Open
spelling doaj-art-f30cbd4ba7ae438192d24833addb4c502025-02-09T05:01:59ZengElsevierJHLT Open2950-13342025-02-017100194Candida dubliniensis breast implant infection in a lung transplant recipientAshley Barnes, MD0Kristen Broderick, MD1Errol Bush, MD2Jonathan Orens, MD3Melanie Marashly, CRNP4Shmuel Shoham, MD5Robin Avery, MD6Division of Infectious Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; Corresponding author: Ashley Barnes, MD, Division of Infectious Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MarylandDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MarylandDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MarylandDepartment of Surgery, Johns Hopkins Hospital, Baltimore, MarylandDivision of Infectious Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MarylandDivision of Infectious Disease, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MarylandThis report details the case of a lung transplant recipient with a remote history of breast cancer and breast reconstruction with implants, who received lengthy antifungal therapy for a post-transplant donor-transmitted Candida dubliniensis empyema. Despite this, she presented months later with a progressive infection of bilateral breast implants, which also proved to be due to Candida dubliniensis. Few cases of breast implant infection after lung transplant have been published. It is possible that biofilm created a barrier to penetration of antifungals, which were able to suppress but not eradicate infection. This case highlights the importance of deep operative cultures for diagnosis and management of infections of this type.http://www.sciencedirect.com/science/article/pii/S2950133424001435Candidainfectionlungtransplantbreast implant
spellingShingle Ashley Barnes, MD
Kristen Broderick, MD
Errol Bush, MD
Jonathan Orens, MD
Melanie Marashly, CRNP
Shmuel Shoham, MD
Robin Avery, MD
Candida dubliniensis breast implant infection in a lung transplant recipient
JHLT Open
Candida
infection
lung
transplant
breast implant
title Candida dubliniensis breast implant infection in a lung transplant recipient
title_full Candida dubliniensis breast implant infection in a lung transplant recipient
title_fullStr Candida dubliniensis breast implant infection in a lung transplant recipient
title_full_unstemmed Candida dubliniensis breast implant infection in a lung transplant recipient
title_short Candida dubliniensis breast implant infection in a lung transplant recipient
title_sort candida dubliniensis breast implant infection in a lung transplant recipient
topic Candida
infection
lung
transplant
breast implant
url http://www.sciencedirect.com/science/article/pii/S2950133424001435
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AT kristenbroderickmd candidadubliniensisbreastimplantinfectioninalungtransplantrecipient
AT errolbushmd candidadubliniensisbreastimplantinfectioninalungtransplantrecipient
AT jonathanorensmd candidadubliniensisbreastimplantinfectioninalungtransplantrecipient
AT melaniemarashlycrnp candidadubliniensisbreastimplantinfectioninalungtransplantrecipient
AT shmuelshohammd candidadubliniensisbreastimplantinfectioninalungtransplantrecipient
AT robinaverymd candidadubliniensisbreastimplantinfectioninalungtransplantrecipient