Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex

Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex

Abstract The aryl hydrocarbon receptor (AHR) possesses an extraordinary capacity to sense and respond to a wide range of small-molecule ligands, ranging from polycyclic aromatic hydrocarbons to endogenous compounds. Upon ligand binding, AHR translocates from the cytoplasm to nucleus, forming a trans...

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Main Authors: Xiaotong Diao, Qinghong Shang, Mengqi Guo, Yubin Huang, Meina Zhang, Xiaoyu Chen, Yinping Liang, Xiangnan Sun, Fan Zhou, Jingjing Zhuang, Shuang-Jiang Liu, Christoph F. A. Vogel, Fraydoon Rastinejad, Dalei Wu
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56574-7
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https://doi.org/10.1038/s41467-025-56574-7

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