Commensal bacteria education history calibrates the naivety and activation threshold of adaptive antiviral immune system

Commensal bacteria education history calibrates the naivety and activation threshold of adaptive antiviral immune system

Exhaustion of the immune system’s ability to adapt to novelty suggests that the changes it undergoes might be a consequence of an evolutionary unpredictable antigenic exposure over a lifetime. Thus, we raise the question of whether a naive immune system can manage new antigens better than an educate...

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Bibliographic Details
Main Authors: Baohua Li, Zhou Sha, Li Mou, Feng Zhang, Lifeng Jia, Yan Zhu, Yan Guo, Guohong Deng, Haibo Wu, Hong Wei, Yuzhang Wu, Lilin Ye, Changjiang Liu, Jian Li, Yanyan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
commensal microbiota
adaptive antiviral immunity
germ-free mice
ABX-treated mice
immune education history
T cell immune effect and memory
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1519023/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1519023/full

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