Cancer stem cells in head and neck squamous cell carcinoma and its associated markers: A review
Evidences of the current research say that cancer is multifactorial with varied mechanisms of origin. Most theories evolve either intrinsic (genetic) or extrinsic factors like tobacco and alcoholism as the major cause of oral cancer in India. There is growing evidence that human papilloma virus may...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_467_23 |
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| _version_ | 1825205588929282048 |
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| author | Lavanya Mallika Mani Rajarathinam Sundararajan Thangavel |
| author_facet | Lavanya Mallika Mani Rajarathinam Sundararajan Thangavel |
| author_sort | Lavanya Mallika |
| collection | DOAJ |
| description | Evidences of the current research say that cancer is multifactorial with varied mechanisms of origin. Most theories evolve either intrinsic (genetic) or extrinsic factors like tobacco and alcoholism as the major cause of oral cancer in India. There is growing evidence that human papilloma virus may act as a co-carcinogen, along with tobacco, in the causation of cancers. The cells being triggered by the agents may be somatic (differentiated functional cell) or a normal stem cell with multipotency or even the transient proliferative cells derived from the stem cells. These stem cells possess several features like slow cell cycle, ability to extrude chemotherapeutic drugs, exhibit epithelial mesenchymal transition, and inhibit apoptosis. Targeting these progenitor stem cells may aid in improving the overall prognosis of the patient. These cancer stem cells are targeted using various markers that are apparently more or less specific to various types of stem cells. |
| format | Article |
| id | doaj-art-f9a7834bfde342abace49f2c83308a02 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-f9a7834bfde342abace49f2c83308a022025-02-07T13:55:42ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-04-0167225025810.4103/ijpm.ijpm_467_23Cancer stem cells in head and neck squamous cell carcinoma and its associated markers: A reviewLavanya MallikaMani RajarathinamSundararajan ThangavelEvidences of the current research say that cancer is multifactorial with varied mechanisms of origin. Most theories evolve either intrinsic (genetic) or extrinsic factors like tobacco and alcoholism as the major cause of oral cancer in India. There is growing evidence that human papilloma virus may act as a co-carcinogen, along with tobacco, in the causation of cancers. The cells being triggered by the agents may be somatic (differentiated functional cell) or a normal stem cell with multipotency or even the transient proliferative cells derived from the stem cells. These stem cells possess several features like slow cell cycle, ability to extrude chemotherapeutic drugs, exhibit epithelial mesenchymal transition, and inhibit apoptosis. Targeting these progenitor stem cells may aid in improving the overall prognosis of the patient. These cancer stem cells are targeted using various markers that are apparently more or less specific to various types of stem cells.https://journals.lww.com/10.4103/ijpm.ijpm_467_23apoptosisautophagycancer stem cellsmetastasisstem cell markers |
| spellingShingle | Lavanya Mallika Mani Rajarathinam Sundararajan Thangavel Cancer stem cells in head and neck squamous cell carcinoma and its associated markers: A review Indian Journal of Pathology and Microbiology apoptosis autophagy cancer stem cells metastasis stem cell markers |
| title | Cancer stem cells in head and neck squamous cell carcinoma and its associated markers: A review |
| title_full | Cancer stem cells in head and neck squamous cell carcinoma and its associated markers: A review |
| title_fullStr | Cancer stem cells in head and neck squamous cell carcinoma and its associated markers: A review |
| title_full_unstemmed | Cancer stem cells in head and neck squamous cell carcinoma and its associated markers: A review |
| title_short | Cancer stem cells in head and neck squamous cell carcinoma and its associated markers: A review |
| title_sort | cancer stem cells in head and neck squamous cell carcinoma and its associated markers a review |
| topic | apoptosis autophagy cancer stem cells metastasis stem cell markers |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_467_23 |
| work_keys_str_mv | AT lavanyamallika cancerstemcellsinheadandnecksquamouscellcarcinomaanditsassociatedmarkersareview AT manirajarathinam cancerstemcellsinheadandnecksquamouscellcarcinomaanditsassociatedmarkersareview AT sundararajanthangavel cancerstemcellsinheadandnecksquamouscellcarcinomaanditsassociatedmarkersareview |