Ultra-processed food intake, genetic polymorphisms, and the risk of dyslipidemia in the adult Korean population
Abstract Objective: This study aimed to examine the association between ultra-processed food intake and dyslipidemia risk, and whether this association varied by the polygenic score for dyslipidemia in the adult Korean population. Design: Prospective cohort study Setting: Ultra-processed foods...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
|
| Series: | Public Health Nutrition |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S1368980024002337/type/journal_article |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861304796905472 |
|---|---|
| author | Minsu Cho Heejin Lee Jung Eun Lee |
| author_facet | Minsu Cho Heejin Lee Jung Eun Lee |
| author_sort | Minsu Cho |
| collection | DOAJ |
| description |
Abstract
Objective:
This study aimed to examine the association between ultra-processed food intake and dyslipidemia risk, and whether this association varied by the polygenic score for dyslipidemia in the adult Korean population.
Design:
Prospective cohort study
Setting:
Ultra-processed foods were identified under the NOVA classification. Participants were categorized into <5, 5 to <10, 10 to <15, 15 to <20, and ≥20%E/d of ultra-processed food intake. The polygenic scores for dyslipidemia were calculated from 53,950 single nucleotide polymorphisms. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariate logistic regression models.
Participants:
20,044 Korean adults aged ≥40 years in the Health Examinees (HEXA) study, the Cardiovascular Disease Association Study (CAVAS), and the Korea Association Resource (KARE) study
Results:
During median follow-ups of 4.09, 8.67, and 15.67 years in the HEXA, CAVAS, and KARE studies, respectively, there were a total of 7,331, 786, and 1,732 incident dyslipidemia events. Ultra-processed food intake was not significantly associated with dyslipidemia risk. Compared with <5%E/d, the pooled OR (95% CI) of ≥20%E/d of ultra-processed food intake for dyslipidemia incidence was 1.01 (0.90, 1.13; p for trend=0.83). There was no interaction by dyslipidemia-related genetic variations; ORs (95% CIs) were 1.04 (0.89, 1.22; p for trend=0.91) and 0.98 (0.84, 1.15; p for trend=0.72) for individuals with high and low polygenic scores, respectively (p for interaction=0.90).
Conclusions:
No significant association was observed between ultra-processed food intake and the overall risk of dyslipidemia, nor in subgroups of polygenic scores for dyslipidemia among Korean adults with low ultra-processed food intake.
|
| format | Article |
| id | doaj-art-fe2719343d5446558d0a8ded0ef91bfb |
| institution | Kabale University |
| issn | 1368-9800 1475-2727 |
| language | English |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Public Health Nutrition |
| spelling | doaj-art-fe2719343d5446558d0a8ded0ef91bfb2025-02-10T02:04:48ZengCambridge University PressPublic Health Nutrition1368-98001475-272712310.1017/S1368980024002337Ultra-processed food intake, genetic polymorphisms, and the risk of dyslipidemia in the adult Korean populationMinsu Cho0Heejin Lee1Jung Eun Lee2https://orcid.org/0000-0003-1141-878XDepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, KoreaDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USADepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea The Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea Abstract Objective: This study aimed to examine the association between ultra-processed food intake and dyslipidemia risk, and whether this association varied by the polygenic score for dyslipidemia in the adult Korean population. Design: Prospective cohort study Setting: Ultra-processed foods were identified under the NOVA classification. Participants were categorized into <5, 5 to <10, 10 to <15, 15 to <20, and ≥20%E/d of ultra-processed food intake. The polygenic scores for dyslipidemia were calculated from 53,950 single nucleotide polymorphisms. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariate logistic regression models. Participants: 20,044 Korean adults aged ≥40 years in the Health Examinees (HEXA) study, the Cardiovascular Disease Association Study (CAVAS), and the Korea Association Resource (KARE) study Results: During median follow-ups of 4.09, 8.67, and 15.67 years in the HEXA, CAVAS, and KARE studies, respectively, there were a total of 7,331, 786, and 1,732 incident dyslipidemia events. Ultra-processed food intake was not significantly associated with dyslipidemia risk. Compared with <5%E/d, the pooled OR (95% CI) of ≥20%E/d of ultra-processed food intake for dyslipidemia incidence was 1.01 (0.90, 1.13; p for trend=0.83). There was no interaction by dyslipidemia-related genetic variations; ORs (95% CIs) were 1.04 (0.89, 1.22; p for trend=0.91) and 0.98 (0.84, 1.15; p for trend=0.72) for individuals with high and low polygenic scores, respectively (p for interaction=0.90). Conclusions: No significant association was observed between ultra-processed food intake and the overall risk of dyslipidemia, nor in subgroups of polygenic scores for dyslipidemia among Korean adults with low ultra-processed food intake. https://www.cambridge.org/core/product/identifier/S1368980024002337/type/journal_articleUltra-processed fooddyslipidemiapolygenic scoresingle nucleotide polymorphism |
| spellingShingle | Minsu Cho Heejin Lee Jung Eun Lee Ultra-processed food intake, genetic polymorphisms, and the risk of dyslipidemia in the adult Korean population Public Health Nutrition Ultra-processed food dyslipidemia polygenic score single nucleotide polymorphism |
| title | Ultra-processed food intake, genetic polymorphisms, and the risk of dyslipidemia in the adult Korean population |
| title_full | Ultra-processed food intake, genetic polymorphisms, and the risk of dyslipidemia in the adult Korean population |
| title_fullStr | Ultra-processed food intake, genetic polymorphisms, and the risk of dyslipidemia in the adult Korean population |
| title_full_unstemmed | Ultra-processed food intake, genetic polymorphisms, and the risk of dyslipidemia in the adult Korean population |
| title_short | Ultra-processed food intake, genetic polymorphisms, and the risk of dyslipidemia in the adult Korean population |
| title_sort | ultra processed food intake genetic polymorphisms and the risk of dyslipidemia in the adult korean population |
| topic | Ultra-processed food dyslipidemia polygenic score single nucleotide polymorphism |
| url | https://www.cambridge.org/core/product/identifier/S1368980024002337/type/journal_article |
| work_keys_str_mv | AT minsucho ultraprocessedfoodintakegeneticpolymorphismsandtheriskofdyslipidemiaintheadultkoreanpopulation AT heejinlee ultraprocessedfoodintakegeneticpolymorphismsandtheriskofdyslipidemiaintheadultkoreanpopulation AT jungeunlee ultraprocessedfoodintakegeneticpolymorphismsandtheriskofdyslipidemiaintheadultkoreanpopulation |