Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein

Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein

Protein-nucleic acid phase separation has been implicated in many diseases such as viral infections, neurodegeneration, and cancer. There is great interest in identifying condensate modulators (CMODs), which are small molecules that alter the dynamics and functions of phase-separated condensates, as...

Full description

Saved in:
Bibliographic Details
Main Authors: Rui Tong Quek, Cyna R. Shirazinejad, Christina L. Young, Kierra S. Hardy, Samuel Lim, Phillip J. Elms, David T. McSwiggen, Timothy J. Mitchison, Pamela A. Silver
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:SLAS Discovery
Subjects:
Biomolecular condensates
High content screening
single molecule tracking
Split luciferase
NanoBRET
Dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555225000139
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2472555225000139

Similar Items